ArticleCanadian geriatrics journal : CGJ2021
Effect of Memantine on Prolonging Safe Driving in Early AD: a Pilot Study.
Article in Canadian geriatrics journal : CGJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
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Abstract
backgroundTo determine the feasibility of conducting an RCT on the potential effectiveness of memantine hydrochloride in prolonging safe driving in mild AD.
methodsA placebo-controlled, double blind randomized trial was conducted. Forty-three individuals ≥60 with mild AD met screening criteria and were randomized. Driving ability was measured by a standardized on-road driving test. Outcomes were driving capacity at 6 and 12 months and completion of the 12-month intervention.
resultsOf 43 participants randomized, 59% of the memantine group and 52% of the placebo group completed the on-road test at 12 months (
conclusionsResults provide the framework for designing a rigorous multisite clinical trial of memantine effect on maintaining driving capacity in mild AD.
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