ArticlePakistan journal of medical sciences
Clinical observation of mild hypothermia combined with intravenous thrombolysis in treating patients with acute cerebral infarction.
Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Target temperature management in acute ischemic stroke.Frontiers in molecular biosciences · 2026Review
- Therapeutic hypothermia for acute ischemic stroke: from preclinical studies to clinical trials.Science China. Life sciences · 2025Review
- A Birth Cohort Study of Neurodevelopmental Outcomes from Birth to 2 Years of Age in Preterm Infants under 34 Weeks of Gestation.Journal of healthcare engineering · 2022Article
- Analysis of the effect of changes in serum osteopontin levels on patients with acute cerebral infarction.Pakistan journal of medical sciencesArticle
- Effect of intravenous thrombolysis combined with endovascular treatment on vascular recanalization rate and peak systolic velocity in patients with acute cerebral infarction.Pakistan journal of medical sciencesArticle
- Clinical efficacy of motor imagery therapy based on fNIRs technology in rehabilitation of upper limb function after acute cerebral infarction.Pakistan journal of medical sciencesArticle
- Effect of clinical pharmacists participating in nutritional therapy for patients with acute cerebral infarction complicated with dysphagia.Pakistan journal of medical sciencesArticle
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4 authors.
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Abstract
objectivesTo investigate the clinical effect of mild hypothermia combined with intravenous thrombolysis in the treatment of acute cerebral infarction.
methodsEighty-eight patients with acute cerebral infarction in Binzhou People's Hospital between May 2018 and August 2019 were randomly selected and divided into a control group and an observation group according to the random number table method, with 44 patients in each group. The control group was given intravenous thrombolysis; the observation group was treated with mild hypothermia (30-35°C) in addition to intravenous thrombolytic thrombolysis. The clinical efficacy, incidence of complications, oxidative stress indexes, inflammatory factor level, neurological function, and mental state of the two groups before and after treatment were compared.
resultsThe clinical efficacy of the observation group was significantly better than that of the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the levels of oxidative stress indexes and inflammatory factors between the two groups before treatment (P<0.05). After treatment, the levels of oxidative stress indexes and inflammatory factors of the two groups significantly improved, and the improvement of the observation group was better than that of the control group; the differences were statistically significant (P<0.05). There was no significant difference in the neurological function and mental state between the two groups before treatment (P<0.05). After treatment, the neurological function and mental state of the two groups significantly improved, and the improvement of the observation group was better than that of the control group; the differences were statistically significant (P<0.05). There was no significant difference in the incidence of complications and mortality between the two groups (P>0.05).
conclusionThrombolytic therapy combined with mild hypothermia has a good efficacy in the treatment of acute cerebral infarction. The therapy can improve the neurological function of patients with acute cerebral infarction by significantly improving the oxidative stress index and relieving the inflammatory reaction. Its efficacy is better than single thrombolytic therapy.
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