Evidence map›Paper›PMID 34912368›Full record

ArticleFrontiers in genetics2021

Case Report: Lennox-Gastaut Epileptic Encephalopathy Responsive to Cannabidiol Treatment Associated With a Novel

Justyna Paprocka, Szymon Ziętkiewicz, Joanna Kosińska, Ewa Kaczorowska, Rafał Płoski

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Justyna PaprockaDepartment of Pediatric Neurologsluy, Faculty of Medical Science in Katowice, Medical University of Silesia, Katowice, Poland.
Szymon ZiętkiewiczDepartment of Medical Genetics, Medical University of Warsaw, Warsaw, Poland.
Joanna KosińskaDepartment of Medical Genetics, Medical University of Warsaw, Warsaw, Poland.
Ewa KaczorowskaDepartment of Biology and Medical Genetics, Medical University of Gdańsk, Gdańsk, Poland.
Rafał PłoskiDepartment of Medical Genetics, Medical University of Warsaw, Warsaw, Poland.
Medical University of Warsaw · PLGdańsk Medical University · PLMedical University of Silesia · PL

Funding

Wellcome Trust
6 · The paper itself

Abstract

The SH3 and multiple ankyrin repeat domains (SHANKs) are a family of scaffolding proteins located in excitatory synapses required for their development and function. Molecular defects of SHANK3 are a well-known cause of several neurodevelopmental entities, in particular autism spectrum disorders and epilepsy, whereas relatively little is known about disease associations of SHANK1. Here, we propose a novel

Indexed as

epilepsyLennox–Gastaut syndromeRap1SHANK1treatment

Identifiers

PMID34912368
PMCPMC8667173
OpenAlexW3216134064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.