ArticleFrontiers in endocrinology2021
Higher Triglyceride-Glucose Index Is Associated With Increased Likelihood of Kidney Stones.
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.
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Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association between the triglyceride-glucose index and kidney stone disease: a systematic review and dose-response meta-analysis.Lipids in health and disease · 2026Pooled it
- The causal relationship between 179 lipid species and urolithiasis: a bidirectional and multivariable Mendelian randomization study combined with meta-analysis.Lipids in health and disease · 2025Pooled it
- Global prevalence of urolithiasis: a meta-analysis accounting for methodological heterogeneity.Frontiers in urology · 2025Pooled it
- Association of Triglyceride-Glucose Index With Different Cardiovascular Diseases in Non-Diabetic Hypertension.Journal of cellular and molecular medicine · 2025Trial
- The effect of SGLT2i on the GH/IGF1 axis in newly diagnosed male T2D patients - a prospective, randomized case-control study.Endocrine · 2024Trial
- Article
- Association between triglyceride levels and upper urinary tract calcium stones recurrence.BMC nephrology · 2026Article
- ZJU index and the prevalence of kidney stones in US adults: evidence from NHANES 2007-2018.BMC urology · 2026Article
- Exploration of the association of antidiabetic drugs with urolithiasis: A drug-targeted Mendelian randomization study.Asian journal of urology · 2026Article
- Relationship between serum glucose-to-albumin ratio and kidney stones among nondiabetic U.S. adults: a population-based study.Translational andrology and urology · 2025Article
- The atherogenic index of plasma increases the risk of incident kidney stones: a nested case-control study in Chinese adults.Renal failure · 2025Article
- Association between the TyG index and MAFLD and its subtypes: a population-based cross-sectional study.BMC gastroenterology · 2025Article
- Exploring the relationship between triglyceride-glucose index and kidney stones in Chinese adults: a cross-sectional study.Translational andrology and urology · 2025Article
- A study on the relationship between the weight-adjusted waist index and kidney stone prevalence mediated by diabetes: data from NHANES 2007-2018.Scientific reports · 2025Article
- Association between ZJU index and kidney stone prevalence in the Chinese adult population: a retrospective propensity score-matched analysis.Urolithiasis · 2025Article
- Observational
- Effect of the plasma metabolites, biomarkers, and inflammatory proteins on urolithiasis: insights from Mendelian randomization and mediation analysis.Urolithiasis · 2025Article
- GOLPH3 promotes calcium oxalate-induced renal injury and fibrosis through Golgi stress-mediated apoptosis and inflammatory responses.Scientific reports · 2025Article
- Associations of triglyceride glucose-related parameters with kidney stones: a cross-sectional study from NHANES 2007-2020.Translational andrology and urology · 2025Article
- The association between TyG index and cardiovascular mortality is modified by antidiabetic or lipid-lowering agent: a prospective cohort study.Cardiovascular diabetology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
Aims: We aimed to assess the association between triglyceride-glucose (TyG) index and kidney stones in US adults. Methods: Data were obtained from the 2007-2014 National Health and Nutrition Examination Survey (NHANES). Participants aged ≥18 years who were not pregnant and provided complete data about TyG index and kidney stones were included in the analysis. Weighted multivariable regression analysis and subgroup analysis were preformed to estimate the independent relationship between TyG index and nephrolithiasis and recurrence. Results: A total of 20,972 participants were included with the mean TyG index of 8.71 ± 0.72. The prevalence rates of nephrolithiasis and recurrence were 9.30% and 3.17% overall and increased with the higher TyG index tertiles (Nephrolithiasis: Tertile 1, 6.98%; Tertile 2, 9.15%; Tertile 3, 11.98%, p < 0.01; Recurrence: Tertile 1, 1.84%; Tertile 2, 3.27%; Tertile 3, 4.50%, p < 0.01). Each unit increase in TyG index was associated with 12% and 26% higher odds of nephrolithiasis [odds ratio (OR) = 1.12; 95% CI: 1.02-1.22; p = 0.02] and recurrence (OR = 1.26; 95% CI: 1.08-1.46; p < 0.01). Interaction tests indicated no significant effect of gender, age, body mass index, hypertension, and diabetes on this association between TyG index and kidney stones. Conclusions: Higher TyG index was associated with an increased likelihood of nephrolithiasis and recurrence. Considering TyG index is a reliable indicator of insulin resistance (IR). Treatment and management of IR at a younger age may improve or alleviate the occurrence and recurrence of kidney stones.
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