ArticleFrontiers in human neuroscience2021
Structural and Functional Abnormalities in Knee Osteoarthritis Pain Revealed With Multimodal Magnetic Resonance Imaging.
Article in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Effects of Acupuncture-Combined Tuina on Patients With Knee Osteoarthritis: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2026Trial
- Effect of acupuncture treatment for patients with knee osteoarthritis on brain fluctuation amplitude and functional connectivity: a randomized three-armed fMRI study.BMC complementary medicine and therapies · 2025Trial
- Early Changes in Resting-State Connectivity of the Anterior Insular Cortex Are Associated with Reductions in Pain and Catastrophizing After Total Hip Arthroplasty in Female Patients: A Preliminary Study.Journal of clinical medicine · 2026Article
- Peripheral inflammation and central sensitization associated with postoperative pain following arthroscopy surgery in rotator cuff injury.La Radiologia medica · 2026Article
- The causal role of brain circuits in osteoarthritis pain.Nature reviews. Rheumatology · 2025Review
- Bridging the gap: Exploring the intercurrent relationship between knee osteoarthritis and cerebral small vessel disease.Caspian journal of internal medicine · 2025Review
- Hippocampal Subfields Related to Cognitive Decline and Peripheral TIM-3 Levels in Elderly with Knee Osteoarthritis.Journal of pain research · 2025Article
- Brain Amyloid-β Peptide Is Associated with Pain Intensity and Cognitive Dysfunction in Osteoarthritic Patients.International journal of molecular sciences · 2024Observational
- The volumes of amygdala subregions and peripheral programmed cell death protein-1 levels are associated with cognitive decline in individuals with knee osteoarthritis.Brain and behavior · 2024Article
- Identification of Specific Abnormal Brain Functional Activity and Connectivity in Cancer Pain Patients: A Preliminary Resting-State fMRI Study.Journal of pain research · 2024Article
- Assessment of Pain in Osteoarthritis of the Knee.Journal of personalized medicine · 2023Review
- Structural and functional brain changes in people with knee osteoarthritis: a scoping review.PeerJ · 2023Article
- Advanced MR Imaging for Knee Osteoarthritis: A Review on Local and Brain Effects.Diagnostics (Basel, Switzerland) · 2022Review
- Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients.Arthritis research & therapy · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The knee osteoarthritis (KOA) pain is the most common form of arthritis pain affecting millions of people worldwide. Long-term KOA pain causes motor impairment and affects affective and cognitive functions. However, little is known about the structural and functional abnormalities induced by long-term KOA pain. In this work, high-resolution structural magnetic resonance imaging (sMRI) and resting-state functional MRI (rs-fMRI) data were acquired in patients with KOA and age-, sex-matched healthy controls (HC). Gray matter volume (GMV) and fractional amplitude of low-frequency fluctuation (fALFF) were used to study the structural and functional abnormalities in patients with KOA. Compared with HC, patients with KOA showed reduced GMV in bilateral insula and bilateral hippocampus, and reduced fALFF in left cerebellum, precentral gyrus, and the right superior occipital gyrus. Patients with KOA also showed increased fALFF in left insula and bilateral hippocampus. In addition, the abnormal GMV in left insula and fALFF in left fusiform were closely correlated with the pain severity or disease duration. These results indicated that long KOA pain leads to brain structural and functional impairments in motor, visual, cognitive, and affective functions that related to brain areas. Our findings may facilitate to understand the neural basis of KOA pain and the future therapy to relieve disease symptoms.
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