ReviewInternational journal of health sciences
Effect of non-surgical periodontal therapy on the serum and crevicular fluid interleukin-10 levels in chronic periodontitis - A systematic review and meta-analysis.
Review in International journal of health sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 citations in OpenAlex.
- Inflammatory and bone remodelling related biomarkers following periodontal transplantation of the tissue engineered biocomplex.Clinical oral investigations · 2024Trial
- Efficacy of injectable platelet-rich fibrin on clinical and biochemical parameters in non-surgical periodontal treatment: a split-mouth randomized controlled trial.Clinical oral investigations · 2023Trial
- Platelet-derived concentrates in the immunological management of periodontitis: from dysbiosis to personalized approaches.Odontology · 2026Review
- Clinical and inflammatory changes following routine scaling and root planing in periodontitis patients with and without diabetes: a prospective observational cohort study.Frontiers in endocrinology · 2026Observational
- Effects of non-surgical periodontal therapy on gingival crevicular fluid CTRP-1, TNF-α, and IL-10 levels.Clinical oral investigations · 2025Article
- Periodontal health status in patients with lung cancer: Case-control study.International journal of health sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of the study was to assess the effect of non-surgical periodontal therapy (NSPT) on the levels of anti-inflammatory cytokine interleukin 10 (IL-10) in serum, gingival crevicular fluid (GCF), and saliva of chronic periodontitis patients.
methodsA comprehensive search was made on PubMed, Embase, and Scopus databases from Jan 2000 to Sep 2020. Three focused questions were addressed: Do GCF, serum, saliva and IL-10 levels change significantly after NSPT? Randomized and Non-Randomized clinical trials were included in the study. Results of the meta-analysis are expressed as standardized mean differences and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines.
resultsA total of 709 studies were retrieved and 17 met the inclusion criteria for systematic review, whereas subgroup meta-analysis was performed on seven studies (GCF-5, serum-2). All studies included had low risk of bias. IL-10levelin GCF showed an increase at 3 months after NSPT with subsequent decrease at 6 months. However, increased serum IL-10 level at 6 months was seen after therapy.
conclusionWithin the limitations, there is moderate evidence that NSPT significantly alters the IL-10 levels in body fluids. IL-10 levels increased in GCF at 3 months whereas decrease was seen at 6 months. Increased IL-10 levels were seen in serum at 6 months.
Indexed as
Identifiers
34912186PMC8589830W3209940641What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.