Evidence map›Paper›PMID 34912121›Full record

ArticleNature2022

Anatomically distinct fibroblast subsets determine skin autoimmune patterns.

Zijian Xu, Daoming Chen, Yucheng Hu, Kaiju Jiang, Huanwei Huang, Yingxue Du, Wenbo Wu, Jiawen Wang, Jianhua Sui, Wenhui Wang and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed, 1 pooled it
24.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

151 citing papers in PubMed, 1 synthesis or guideline pooled it, 314 citations in OpenAlex.

  1. Guideline
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  11. Design, synthesis, and activity study of heterocyclic derivatives as JAK inhibitors.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Article
  12. CD73Nature communications · 2026
    Article
  13. The immunology of vitiligo.Nature reviews. Immunology · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Melanocyte loss dominates the vitiligo transcriptome: a rank-based meta-analysis.medRxiv : the preprint server for health sciences · 2026
    Article
  19. Article
  20. Article

91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Zijian Xu *National Institute of Biological Sciences, Beijing, China.
Daoming Chen *National Institute of Biological Sciences, Beijing, China.
Yucheng HuAcademy for Multidisciplinary Studies, Beijing National Center for Applied Mathematics, Beijing Advanced Innovation Center for Imaging Theory and Technology, Capital Normal University, Beijing, China.
Kaiju JiangNational Institute of Biological Sciences, Beijing, China.
Huanwei HuangNational Institute of Biological Sciences, Beijing, China.
Yingxue DuNational Institute of Biological Sciences, Beijing, China.
Wenbo WuNational Institute of Biological Sciences, Beijing, China.
Jiawen WangNational Institute of Biological Sciences, Beijing, China.
Jianhua SuiNational Institute of Biological Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-1272-9662
Wenhui WangPeking University Third Hospital, Beijing, China.
Long ZhangPeking University Third Hospital, Beijing, China.
Shuli LiDepartment of Dermatology, Xijing Hospital, Xi'an, China.
Chunying LiDepartment of Dermatology, Xijing Hospital, Xi'an, China.ORCID http://orcid.org/0000-0003-3004-5376
Yong YangInstitute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.ORCID http://orcid.org/0000-0002-7668-3309
Jianmin ChangDepartment of Dermatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China. changjm0417@126.com.
Ting ChenNational Institute of Biological Sciences, Beijing, China. chenting@nibs.ac.cn.ORCID http://orcid.org/0000-0002-7404-4538
National Institute of Biological Sciences, Beijing · CNPeking University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNXijing Hospital · CNCapital Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The skin serves as a physical barrier and an immunological interface that protects the body from the external environment

Indexed as

AdolescentAdultAnimalsAutoimmune DiseasesCD8-Positive T-LymphocytesChemokine CXCL10Chemokine CXCL9ChildDisease Models, AnimalFemaleFibroblastsHumansInterferon-gammaMaleMelanocytesMiceChemokine CXCL10Chemokine CXCL9Interferon-gamma

Identifiers

PMID34912121
OpenAlexW4200436377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.