ArticleNature2022
Spatial genomics enables multi-modal study of clonal heterogeneity in tissues.
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In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 176 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
176citing papers in PubMed, 1 pooled it
16.3field-weighted citation impact, top 1% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
176 citing papers in PubMed, 1 synthesis or guideline pooled it, 254 citations in OpenAlex.
- Machine learning approaches for EGFR mutation status prediction in NSCLC: an updated systematic review.Frontiers in oncology · 2025Pooled it
- Estimation of cell lineages in tumors from spatial transcriptomics data.Nature communications · 2023Trial
- A single-cell lens into the co-evolution of genotypes and phenotypes in cancer.Nature reviews. Cancer · 2026Review
- Spatiotemporal Resolution for Neurodegenerative Diseases: Linking Proteinopathy, Cellular Vulnerability, and Disease Trajectories.Neuroscience bulletin · 2026Review
- Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma.Molecular oncology · 2026Article
- Computational approaches for multimodal lineage tracing.Nature reviews. Genetics · 2026Review
- Spatial chromatin architecture and accessibility co-profiling of mammalian tissues.Nature methods · 2026Article
- 3D multi-omics tumour atlases: from technology to biology and clinical translation.Nature reviews. Cancer · 2026Review
- Insights Into Spatial Transcriptomics: Exploring Recent Technical Developments and Their Diverse Applications.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Review
- Benchmarking copy number alteration inference methods for spatial transcriptomics.Nature communications · 2026Article
- Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis.Nature genetics · 2026Article
- Disulfidptosis: Mechanisms, evidence boundaries, and translational opportunities.Redox biology · 2026Review
- Spatial omics illuminates tumor heterogeneity.Cell reports methods · 2026Review
- Tumor evolution: signaling pathways, molecular mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- STGBench: sequencing-level spatial DNA-RNA simulation for multimodal and virtual cell-oriented benchmarking of genomic alterations.Briefings in bioinformatics · 2026Article
- 3D pathology-guided microdissection.Nature methods · 2026Article
- Spatially resolved profiling of extracellular vesicles in tissues with Spatial-EV-seq.Nature biotechnology · 2026Article
- Spatially tunable multiomic sequencing using light-driven combinatorial barcoding of molecules in tissues.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mapping the genetic landscape of hereditary diffuse-type gastric cancer progression.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Article
116 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Tongtong Zhao *Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Zachary D Chiang *Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Julia W MorrissBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Lindsay M LaFaveDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Evan M MurrayBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Isabella Del PrioreDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Kevin MeliDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-9579-3829
Caleb A LareauBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-4179-4807
Naeem M NadafBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Jilong LiBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Andrew S EarlBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-5732-954X
Evan Z MacoskoBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-2794-5165
Tyler JacksBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5785-8911
Jason D BuenrostroBroad Institute of MIT and Harvard, Cambridge, MA, USA. jason_buenrostro@harvard.edu.ORCID http://orcid.org/0000-0001-9958-3987
Fei ChenBroad Institute of MIT and Harvard, Cambridge, MA, USA. chenf@broadinstitute.org.ORCID http://orcid.org/0000-0003-2308-3649
Broad Institute · USMassachusetts Institute of Technology · USHarvard University · US
Funding
Training Program in Bioinformatics and Integrative GenomicsT32HG002295 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Peter J Park · 2001 to 2026
$15.8MCOVID19 Slide-seqR01HG010647 · NHGRI · BROAD INSTITUTE, INC. · PI Fei Chen, Evan Z Macosko · 2019 to 2026
$6.0MSingle-cell epigenomic and cellular plasticityDP2HL151353 · NHLBI · HARVARD UNIVERSITY · PI BUENROSTRO, JASON DANIEL · 2019 to 2019
$2.5MCharacterizing glioma heterogeneity with novel multiplexed nanoscale imaging technologiesDP5OD024583 · OD · BROAD INSTITUTE, INC. · PI CHEN, FEI · 2017 to 2021
$2.2MImplementation of Slide-seq for high-resolution, whole-transcriptome human tissue maps.UH3CA246632 · NCI · BROAD INSTITUTE, INC. · PI MACOSKO, EVAN Z · 2019 to 2021
$1.9MIMAT-ITCR Collaboration: An integrated experimental and computational platform for analyzing the spatial organization of tumor clonesR33CA246455 · NCI · BROAD INSTITUTE, INC. · PI ASHENBERG, ORR, CHEN, FEI · 2020 to 2022
$1.4MIn situ ATAC-seq, a novel technology for structural epigenomicsR21HG009749 · NHGRI · BROAD INSTITUTE, INC. · PI BUENROSTRO, JASON DANIEL, CHEN, FEI · 2017 to 2018
$708kNCI NIH HHS R33 CA246455NCI NIH HHS UH3 CA246632NHGRI NIH HHS R01 HG010647NHGRI NIH HHS R21 HG009749NHGRI NIH HHS T32 HG002295NHLBI NIH HHS DP2 HL151353NIH HHS DP5 OD024583Wellcome Trust
Abstract
The state and behaviour of a cell can be influenced by both genetic and environmental factors. In particular, tumour progression is determined by underlying genetic aberrations
Indexed as
AnimalsClone CellsColorectal NeoplasmsDNA Copy Number VariationsGenomicsHumansMicePhenotypeRNA-SeqSequence Analysis, DNATranscription, GeneticTranscriptome
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What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.