Evidence map›Paper›PMID 34912114›Full record

ArticleNature2022

Individual human cortical progenitors can produce excitatory and inhibitory neurons.

Ryan N Delgado, Denise E Allen, Matthew G Keefe, Walter R Mancia Leon, Ryan S Ziffra, Elizabeth E Crouch, Arturo Alvarez-Buylla, Tomasz J Nowakowski

Open access · greenAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 192 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Isolation of postnatal human neural stem cells.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Multimodal classification of neurons in the lateral septum.bioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Disease insights from brain somatic mosaicism.Experimental & molecular medicine · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Bridging unpaired single-cell multimodal data for integrative analyses with SuperMap.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  16. Impact of Prenatal Alcohol Exposure on Cerebral Cortex Development.Advances in experimental medicine and biology · 2026
    Review
  17. Article
  18. Article
  19. Review
  20. Article

56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ryan N Delgado *Department of Anatomy, University of California at San Francisco, San Francisco, CA, USA. Ryan.N.Delgado@gmail.com.ORCID http://orcid.org/0000-0002-7551-0182
Denise E Allen *Department of Anatomy, University of California at San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9205-2796
Matthew G Keefe *Department of Anatomy, University of California at San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-2477-2975
Walter R Mancia LeonThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California at San Francisco, San Francisco, CA, USA.
Ryan S ZiffraDepartment of Anatomy, University of California at San Francisco, San Francisco, CA, USA.
Elizabeth E CrouchThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California at San Francisco, San Francisco, CA, USA.
Arturo Alvarez-BuyllaThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California at San Francisco, San Francisco, CA, USA.
Tomasz J NowakowskiDepartment of Anatomy, University of California at San Francisco, San Francisco, CA, USA. Tomasz.Nowakowski@ucsf.edu.ORCID http://orcid.org/0000-0003-2345-4964
University of California, San Francisco · USBroad Center · US

Funding

The Psychiatric Cell Map Initiative: Connecting Genomics, Subcellular Networks, and Higher Order PhenotypesU01MH115747 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAMPMANN, MARTIN, KROGAN, NEVAN J · 2018 to 2022
$19.6M
NEUROGENESIS IN THE ADULT VERTEBRATE BRAINR01NS028478 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVAREZ-BUYLLA, ARTURO · 1996 to 2024
$8.6M
PREDOCTORAL TRAINING IN DEVELOPMENTAL BIOLOGYT32HD007470 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Todd Nystul · 1994 to 2026
$7.7M
Assessing Genomic, Regulatory and Transcriptional Variation at Single Nuclei Resolution in the Brains of Individuals with Autism Spectrum DisorderR01MH125516 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ARNOLD KRIEGSTEIN, Tomasz Nowakowski · 2021 to 2026
$3.8M
Interneuron Precursors and the induction of cortical plasticityR01EY025174 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVAREZ-BUYLLA, ARTURO, HASENSTAUB, ANDREA RAYNE · 2015 to 2019
$2.1M
Mapping Developmental Lineage Relationships in the Cerebral CortexRF1MH121268 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOWAKOWSKI, TOMASZ · 2019 to 2019
$2.1M
Mural stem cells in normal development and germinal matrix hemorrhage in the preterm human brainK08NS116161 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CROUCH, ELIZABETH ERIN · 2021 to 2025
$1.1M
NEI NIH HHS R01 EY025174NICHD NIH HHS T32 HD007470NIMH NIH HHS R01 MH125516NIMH NIH HHS RF1 MH121268NIMH NIH HHS U01 MH115747NINDS NIH HHS K08 NS116161NINDS NIH HHS R01 NS028478
6 · The paper itself

Abstract

The cerebral cortex is a cellularly complex structure comprising a rich diversity of neuronal and glial cell types. Cortical neurons can be broadly categorized into two classes-excitatory neurons that use the neurotransmitter glutamate, and inhibitory interneurons that use γ-aminobutyric acid (GABA). Previous developmental studies in rodents have led to a prevailing model in which excitatory neurons are born from progenitors located in the cortex, whereas cortical interneurons are born from a separate population of progenitors located outside the developing cortex in the ganglionic eminences

Indexed as

Cell LineageCerebral CortexInterneuronsNeural InhibitionNeuronsGABAergic NeuronsHumans

Identifiers

PMID34912114
PMCPMC8994470
OpenAlexW4200114667

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.