Evidence map›Paper›PMID 34912073›Full record

ArticleBritish journal of cancer2022

Detection of recurrences using serum miR-371a-3p during active surveillance in men with stage I testicular germ cell tumours.

Christian D Fankhauser, Ailsa J Christiansen, Christian Rothermundt, Richard Cathomas, Marian S Wettstein, Nico C Grossmann, Josias B Grogg, Arnoud J Templeton, Anita Hirschi-Blickenstorfer, Anja Lorch and 4 more

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Article in British journal of cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 50 citations in OpenAlex.

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  15. Detection of Recurrence through microRNA-371a-3p Serum Levels in a Follow-up of Stage I Testicular Germ Cell Tumors in the DRKS-00019223 Study.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Christian D Fankhauser *Department of Urology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. cdfankhauser@gmail.com.ORCID http://orcid.org/0000-0002-4073-5488
Ailsa J Christiansen *Department of Urology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Christian RothermundtDepartment of Oncology, Kantonsspital, St. Gallen, Switzerland.
Richard CathomasDepartment of Oncology, Kantonsspital Chur, Chur, Switzerland.
Marian S WettsteinDepartment of Urology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Nico C GrossmannDepartment of Urology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Josias B GroggDepartment of Urology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Arnoud J TempletonDepartment of Medical Oncology, St. Claraspital Basel and Faculty of Medicine, University of Basel, Basel, Switzerland.
Anita Hirschi-BlickenstorferOnkozentrum Hirslanden, Klinik Hirslanden, Zürich, Switzerland.
Anja LorchDepartment of Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Silke GillessenDepartment of Oncology, Kantonsspital, St. Gallen, Switzerland.
Holger MochDepartment of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Joerg BeyerDepartment of Medical Oncology, Inselspital, University Hospital, University of Bern, Bern, Switzerland.
Thomas HermannsDepartment of Urology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
University of Zurich · CHUniversity of Bern · CHKantonsspital Graubünden · CHKantonsspital St. Gallen · CHKlinik Hirslanden · CHUniversity of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMiR-371a-3p predicts the presence of a macroscopic non-teratomatous germ cell tumour (GCT). We hypothesised that miR-371a-3p can also detect recurrence during active surveillance (AS) of stage I GCT.

methodsWe prospectively collected serum samples of 33 men. Relative expression of serum miR-371a-3p levels was determined at each follow-up visit using real-time quantitative reverse transcription-polymerase chain reaction.

resultsRecurrence was detected using standard follow-up investigations in 10/33 patients (30%) after a median of 7 months. Directly after orchiectomy, miR-371a-3p levels were not elevated in any of the 15 patients with available post-orchiectomy samples. However, all ten recurring patients exhibited increasing miR-371a-3p levels during follow-up, while miR-371a-3p levels remained non-elevated in all but one patient without recurrence. MiR-371a-3p detected recurrences at a median of 2 months (range 0-5) earlier than standard follow-up investigations.

conclusionsMiR-371a-3p levels immediately post orchiectomy are not predictive for recurrences and unfortunately cannot support decision-making for AS vs. adjuvant treatment. However, miR-371a-3p detects recurrences reliably and earlier than standard follow-up investigations. If this can be confirmed in larger cohorts, monitoring miR-371a-3p could replace surveillance imaging in seminomatous GCT and reduce the amount of imaging in non-seminomatous GCT. Earlier detection of disease recurrence may also reduce the overall treatment burden.

Indexed as

Neoplasms, Germ Cell and EmbryonalTesticular NeoplasmsBiomarkers, TumorHumansMaleMicroRNAsNeoplasm Recurrence, LocalWatchful WaitingBiomarkers, TumorMicroRNAsMIRN371 microRNA, human

Identifiers

PMID34912073
PMCPMC9023438
OpenAlexW4200444825

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.