ArticleNature communications2021
Oxicam-type non-steroidal anti-inflammatory drugs inhibit NPR1-mediated salicylic acid pathway.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- A VvWRKY8-salicylic acid pathway amplification loop confers resistance to Plasmopara viticola in grapevine.Molecular horticulture · 2026Article
- UGT76B1 and 41 Additional Arabidopsis UDP-Glycosyltransferases Show No Detectable In Vitro Glycosylation Activity TowardLife (Basel, Switzerland) · 2026Article
- Poplar miR1447 Is a Negative Regulator of Disease Resistance Through the SA-Dependent Pathway.Plant biotechnology journal · 2026Article
- A copper-dependent redox-based hydrogen peroxide perception in plants.Nature communications · 2026Article
- Establishment of a TRV-VIGS system in Coix (Frontiers in plant science · 2026Article
- Decursin, Identified via High-Throughput Chemical Screening, Enhances Plant Disease Resistance via Two Independent Mechanisms.Molecular plant pathology · 2025Article
- The Characteristics and Biological Activities of Niosome-Entrapped Salicylic Acid-Contained Oleoresin fromAdvances in pharmacological and pharmaceutical sciences · 2024Article
- Inhibition of NPR1 Leads to Shoot Growth Improvement under Low-Calcium Conditions in Arabidopsis.Plant & cell physiology · 2023Article
- Chemical inhibition of Arabidopsis PIN-FORMED auxin transporters by the anti-inflammatory drug naproxen.Plant communications · 2023Article
- Transcriptional regulation of plant innate immunity.Essays in biochemistry · 2022Review
- Oxicam-type nonsteroidal anti-inflammatory drugs enhancePlant biotechnology (Tokyo, Japan) · 2022Article
- Comparison of the pathway structures influencing the temporal response of salicylate and jasmonate defence hormones inFrontiers in plant science · 2022Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs), including salicylic acid (SA), target mammalian cyclooxygenases. In plants, SA is a defense hormone that regulates NON-EXPRESSOR OF PATHOGENESIS RELATED GENES 1 (NPR1), the master transcriptional regulator of immunity-related genes. We identify that the oxicam-type NSAIDs tenoxicam (TNX), meloxicam, and piroxicam, but not other types of NSAIDs, exhibit an inhibitory effect on immunity to bacteria and SA-dependent plant immune response. TNX treatment decreases NPR1 levels, independently from the proposed SA receptors NPR3 and NPR4. Instead, TNX induces oxidation of cytosolic redox status, which is also affected by SA and regulates NPR1 homeostasis. A cysteine labeling assay reveals that cysteine residues in NPR1 can be oxidized in vitro, leading to disulfide-bridged oligomerization of NPR1, but not in vivo regardless of SA or TNX treatment. Therefore, this study indicates that oxicam inhibits NPR1-mediated SA signaling without affecting the redox status of NPR1.
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