Evidence map›Paper›PMID 34911839›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2021

Efficacy and safety of vagus nerve stimulation in the treatment of refractory epilepsy.

Zhuanyi Yang, Dingyang Liu, Zhiquan Yang, Xiaoyu Chen, Yuxiang Cai, Jian Liu, Junmei Zhang, Sushan Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Zhuanyi YangDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China. neuroyzy@csu.edu.cn.
Dingyang LiuDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhiquan YangDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China. y66406914@163.com.
Xiaoyu ChenDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Yuxiang CaiDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Jian LiuDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Junmei ZhangDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Sushan LiDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
Xiangya Hospital Central South University · CNCentral South University · CN

Funding

the National Key Research and Development Program of China 2016YFC0105901XYY
6 · The paper itself

Abstract

objectivesVagus nerve stimulation (VNS) is a neuromodulative therapeutic technique for patients with drug-resistant epilepsy who are not suitable for resection or who have experienced a failed resection. This study aims to explore the efficacy and safety of VNS in patients with refractory epilepsy, and to analyze the influential factors for the efficacy.

methodsA retrospective review of clinical data were conducted for 35 patients, who were treated for refractory epilepsy through VNS surgery in the Department of Neurosurgery, Xiangya Hospital, Central South University from April 2016 to August 2019. All patients were analyzed in terms of the clinical and follow-up data.

resultsAfter a mean follow-up of 26 months (6-47 months), outcome was as follows: 7 patients were MuHugh class I, 13 patients were MuHugh class II, 8 patients were MuHugh class III, and 7 patients were MuHugh class IV-V. The total efficacy rate in the short duration group was significantly higher than that in the long duration group (77.8% vs 50.0%,

conclusionsVNS is a safe and effective option in treating patients with refractory epilepsy, especially for those with short duration.

Indexed as

Drug Resistant EpilepsyVagus Nerve StimulationHumansMagnetic Resonance ImagingRetrospective StudiesSeizuresTreatment OutcomeMcHugh seizure outcome classificationsrefractory epilepsyvagus nerve stimulation

Identifiers

PMID34911839
PMCPMC10930241
OpenAlexW4200133798

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.