Evidence map›Paper›PMID 34911838›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2021

Abnormal neurobiochemical metabolites in the first

Lijun Ouyang, Wenxiao Zheng, Xiaoqian Ma, Liu Yuan, Ying He, Xiaogang Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 75% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lijun OuyangMental Health Institute, Second Xiangya Hospital, Central South University; China National Technology Institute on Mental Disorders; National Technology Institute on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health; Hunan Medical Center for Mental Health, Changsha 410011, China. lijunouyang@csu.edu.cn.
Wenxiao ZhengMental Health Institute, Second Xiangya Hospital, Central South University; China National Technology Institute on Mental Disorders; National Technology Institute on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health; Hunan Medical Center for Mental Health, Changsha 410011, China.
Xiaoqian MaMental Health Institute, Second Xiangya Hospital, Central South University; China National Technology Institute on Mental Disorders; National Technology Institute on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health; Hunan Medical Center for Mental Health, Changsha 410011, China.
Liu YuanMental Health Institute, Second Xiangya Hospital, Central South University; China National Technology Institute on Mental Disorders; National Technology Institute on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health; Hunan Medical Center for Mental Health, Changsha 410011, China.
Ying HeMental Health Institute, Second Xiangya Hospital, Central South University; China National Technology Institute on Mental Disorders; National Technology Institute on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health; Hunan Medical Center for Mental Health, Changsha 410011, China. yinghe@csu.edu.cn.
Xiaogang ChenMental Health Institute, Second Xiangya Hospital, Central South University; China National Technology Institute on Mental Disorders; National Technology Institute on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health; Hunan Medical Center for Mental Health, Changsha 410011, China. Chenxiaogang@csu.edu.cn.
Central South University · CN

Funding

the National Natural Science Foundation of China 81871056
6 · The paper itself

Abstract

objectivesTo explore the metabolite characteristics in medial prefrontal cortex (mPFC) by

methodsA total of 46 patients with the first-episode schizophrenia (FES), 49 people with clinical high risk (CHR), 61 people with genetic high risk (GHR), and 58 healthy controls (HC) were enrolled. The levels of N-acetylaspartylglutamate+N-acetylaspartate (tNAA), choline-containing compounds (Cho) and myo-inositol (MI), glutamate+glutamine (Glx) in medial prefrontal cortex were measured by single-voxel

resultsThere were significant differences in Glx, tNAA, and MI concentrations among 4 groups (all

conclusionsThe decreased levels of MI and Glx in the FES patients suggest that there may be glial functional damage and glutamatergic transmitter dysfunction in the early stage of the disease. The compensatory increase of metabolites may be a protective factor for schizophrenia in the genetic individuals.

Indexed as

SchizophreniaAspartic AcidGlutamic AcidGlutamineHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyProton Magnetic Resonance SpectroscopyAspartic AcidGlutamic AcidGlutaminefirst-episode schizophreniahigh-risk populationmagnetic resonance spectroscopy

Identifiers

PMID34911838
PMCPMC10930238
OpenAlexW4200196155

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.