Evidence map›Paper›PMID 34911810›Full record

ArticleLife science alliance2022

Loss of Nup210 results in muscle repair delays and age-associated alterations in muscle integrity.

Stephen Sakuma, Ethan Ys Zhu, Marcela Raices, Pan Zhang, Rabi Murad, Maximiliano A D'Angelo

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Advances in the understanding of nuclear pore complexes in human diseases.Journal of cancer research and clinical oncology · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Stephen SakumaCell and Molecular Biology of Cancer Program, National Cancer Institute (NCI)-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID 0000-0002-0779-5139
Ethan Ys ZhuCell and Molecular Biology of Cancer Program, National Cancer Institute (NCI)-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Marcela RaicesCell and Molecular Biology of Cancer Program, National Cancer Institute (NCI)-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Pan ZhangBioinformatics Core, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Rabi MuradBioinformatics Core, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Maximiliano A D'AngeloCell and Molecular Biology of Cancer Program, National Cancer Institute (NCI)-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA mdangelo@sbpdiscovery.org.ORCID 0000-0001-7025-0142
Sanford Burnham Prebys Medical Discovery Institute · US

Funding

Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ELENA B PASQUALE · 1985 to 2026
$107.2M
Characterizing the nuclear pore complex-T cell receptor connectionR01AI148668 · NIAID · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI DANGELO, MAXIMILIANO A · 2020 to 2024
$3.3M
Mechanisms of Nup210 Regulation of Muscle Development and RegenerationR01AR065083 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DANGELO, MAXIMILIANO A · 2014 to 2018
$2.8M
Nuclear pore regulation of leukemia cell metabolism and survivalR21CA244028 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI RAICES, MARCELA · 2020 to 2021
$501k
NCI NIH HHS P30 CA030199NCI NIH HHS R21 CA244028NIAID NIH HHS R01 AI148668NIAMS NIH HHS R01 AR065083
6 · The paper itself

Abstract

Nuclear pore complexes, the channels connecting the nucleus with the cytoplasm, are built by multiple copies of ∼30 proteins called nucleoporins. Recent evidence has exposed that nucleoporins can play cell type-specific functions. Despite novel discoveries into the cellular functions of nucleoporins, their role in the regulation of mammalian tissue physiology remains mostly unexplored because of a limited number of nucleoporin mouse models. Here we show that ablation of Nup210/Gp210, a nucleoporin previously identified to play a role in myoblast differentiation and Zebrafish muscle maturation, is dispensable for skeletal muscle formation and growth in mice. We found that although primary satellite cells from

Indexed as

PhenotypeAge FactorsAnimalsCell DifferentiationFluorescent Antibody TechniqueGene Expression RegulationMiceMice, KnockoutMuscle DevelopmentMusclesNuclear Pore Complex ProteinsRegenerationSatellite Cells, Skeletal MuscleNuclear Pore Complex ProteinsNup210 protein, mouse

Identifiers

PMID34911810
PMCPMC8711851
OpenAlexW4200219471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.