Evidence map›Paper›PMID 34911797›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Late-Onset, Short-Term Intermittent Fasting Reverses Age-Related Changes in Calcium Buffering and Inhibitory Synaptic Transmission in Mouse Basal Forebrain Neurons.

Eunyoung Bang, Annette S Fincher, Sophie Nader, David A Murchison, William H Griffith

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Intermittent Fasting andNutrients · 2026
    Article
  3. Article
  4. Photosensitivity of an aging brain.bioRxiv : the preprint server for biology · 2025
    Article
  5. The cold truth: torpor as a confound in studies of caloric restriction.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025
    Review
  6. Article
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Eunyoung BangDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health, Bryan, Texas 77807.ORCID 0000-0002-7986-8448
Annette S FincherDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health, Bryan, Texas 77807.
Sophie NaderDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health, Bryan, Texas 77807.
David A MurchisonDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health, Bryan, Texas 77807.
William H GriffithDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health, Bryan, Texas 77807 whgriff@tamu.edu.
Texas A&M Health Science Center · US

Funding

Optogenetic approaches to study complex neuronal circuits during cognitive agingR01AG047652 · NIA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI GRIFFITH, WILLIAM H · 2014 to 2018
$1.6M
NIA NIH HHS R01 AG047652
6 · The paper itself

Abstract

Aging is often associated with cognitive decline and recurrent cellular and molecular impairments. While life-long caloric restriction (CR) may delay age-related cognitive deterioration as well as the onset of neurologic disease, recent studies suggest that late-onset, short-term intermittent fasting (IF), may show comparable beneficial effects as those of life-long CR to improve brain health. We used a new optogenetic aging model to study the effects of late-onset (>18 months), short-term (four to six weeks) IF on age-related changes in GABAergic synaptic transmission, intracellular calcium (Ca

Indexed as

AgingAnimalsBasal ForebrainCalciumFastingMaleMiceMice, TransgenicNeuronsOptogeneticsSynaptic TransmissionCalciumagingbasal forebraincalciumcognitionintermittent fastingsynaptic

Identifiers

PMID34911797
PMCPMC8824495
OpenAlexW4200352938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.