Evidence map›Paper›PMID 34911781›Full record

ArticleCancer research2021

Coiled-Coil Domain: Uncoiling Tumor Suppression by BRCA1.

Arun P Mishra, Sounak Sahu, Shyam K Sharan

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Genes · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Arun P MishraMouse Cancer Genetics Program, Center for Cancer Research, NCI, NIH, Frederick, Maryland.ORCID 0000-0001-6558-1166
Sounak SahuMouse Cancer Genetics Program, Center for Cancer Research, NCI, NIH, Frederick, Maryland.ORCID 0000-0001-7290-6651
Shyam K SharanMouse Cancer Genetics Program, Center for Cancer Research, NCI, NIH, Frederick, Maryland. sharans@mail.nih.gov.ORCID 0000-0002-9333-870X
Center for Cancer Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coiled-coil domain of BRCA1 is essential for its interaction with partner and localizer of BRCA2 (PALB2). In mice, loss of this interaction is known to result in Fanconi anemia-associated phenotypes. In a study published in this issue of

Indexed as

NeoplasmsTumor Suppressor ProteinsAnimalsBRCA1 ProteinFanconi Anemia Complementation Group N ProteinMiceBRCA1 ProteinFanconi Anemia Complementation Group N ProteinTumor Suppressor Proteins

Identifiers

PMID34911781
OpenAlexW4200582088

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.