Evidence map›Paper›PMID 34911767›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Human leukocytes selectively convert 4

Ashley E Shay, Robert Nshimiyimana, Bengt Samuelsson, Nicos A Petasis, Jesper Z Haeggström, Charles N Serhan

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. SiOScientific reports · 2025
    Article
  5. Article
  6. Article
  7. Biosynthesis of resolvin D1, resolvin D2, and RCTR1 from 7,8(S,S)-epoxytetraene in human neutrophils and macrophages.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. 15-epi-lipoxin AFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  9. Review
  10. Review
  11. Article
  12. Role of Resolvins in Inflammatory and Neuropathic Pain.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  13. Article
  14. Resolvin D1 prevents injurious neutrophil swarming in transplanted lungs.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ashley E ShayCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.ORCID 0000-0003-4501-680X
Robert NshimiyimanaCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
Bengt SamuelssonDivision of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S-171 77 Stockholm, Sweden; bengt.samuelsson@ki.se cserhan@bwh.harvard.edu.
Nicos A PetasisDepartment of Chemistry, Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, CA 90089.ORCID 0000-0002-8864-4446
Jesper Z HaeggströmDivision of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S-171 77 Stockholm, Sweden.ORCID 0000-0002-1823-5153
Charles N SerhanCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115; bengt.samuelsson@ki.se cserhan@bwh.harvard.edu.ORCID 0000-0003-4627-8545
Brigham and Women's Hospital · USKarolinska Institutet · SEUniversity of Southern California · US

Funding

Resolution Mechanisms in Acute Inflammation: Resolution PharmacologyP01GM095467 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 2011 to 2020
$14.8M
Evaluating Resolution Mechanisms for Infectious InflammationR35GM139430 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 2021 to 2025
$3.6M
NIGMS NIH HHS P01 GM095467NIGMS NIH HHS R35 GM139430
6 · The paper itself

Abstract

Human phagocytes have key functions in the resolution of inflammation. Here, we assessed the role of the proposed 4

Indexed as

Cells, CulturedFatty Acids, UnsaturatedGranulomaHumansLeukocytesMacrophagesFatty Acids, Unsaturatedresolvin D3resolvin D4biosynthesiscys-SPMmacrophageneutrophilresolution

Identifiers

PMID34911767
PMCPMC8713978
OpenAlexW4200323921

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.