Evidence map›Paper›PMID 34911764›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Tissue compartmentalization enables

Jiagui Li, Beatrice Claudi, Joseph Fanous, Natalia Chicherova, Francesca Romana Cianfanelli, Robert A A Campbell, Dirk Bumann

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

  1. Microorganisms · 2026
    Review
  2. Article
  3. Antibiotic-recalcitrant Salmonella during infection.Nature reviews. Microbiology · 2025
    Review
  4. Article
  5. Reactivation of hidden-latentAntimicrobial agents and chemotherapy · 2025
    Article
  6. ConcurrentmSphere · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Intracellular persister: A stealth agent recalcitrant to antibiotics.Frontiers in cellular and infection microbiology · 2023
    Review
  12. Review
  13. Article
  14. Antibiotic persistence of intracellular Brucella abortus.PLoS neglected tropical diseases · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jiagui LiBiozentrum, University of Basel, CH-4056 Basel, Switzerland.
Beatrice ClaudiBiozentrum, University of Basel, CH-4056 Basel, Switzerland.ORCID 0000-0002-0140-335X
Joseph FanousBiozentrum, University of Basel, CH-4056 Basel, Switzerland.ORCID 0000-0002-5076-547X
Natalia ChicherovaBiozentrum, University of Basel, CH-4056 Basel, Switzerland.ORCID 0000-0001-7899-0348
Francesca Romana CianfanelliBiozentrum, University of Basel, CH-4056 Basel, Switzerland.ORCID 0000-0002-4570-1877
Robert A A CampbellBiozentrum, University of Basel, CH-4056 Basel, Switzerland.ORCID 0000-0002-8330-4477
Dirk BumannBiozentrum, University of Basel, CH-4056 Basel, Switzerland dirk.bumann@unibas.ch.ORCID 0000-0003-3636-4239
University of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial chemotherapy can fail to eradicate the pathogen, even in the absence of antimicrobial resistance. Persisting pathogens can subsequently cause relapsing diseases. In vitro studies suggest various mechanisms of antibiotic persistence, but their in vivo relevance remains unclear because of the difficulty of studying scarce pathogen survivors in complex host tissues. Here, we localized and characterized rare surviving

Indexed as

AnimalsAnti-Bacterial AgentsEnrofloxacinMiceMice, Inbred BALB CSalmonella Infections, AnimalSalmonella typhimuriumAnti-Bacterial AgentsEnrofloxacin3D microscopyantimicrobial chemotherapybacterial infectionsalmonellosistreatment failure

Identifiers

PMID34911764
PMCPMC8713819
OpenAlexW4200106534

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.