Evidence map›Paper›PMID 34911745›Full record

ArticleImmunoHorizons2021

Class Ib MHC-Mediated Immune Interactions Play a Critical Role in Maintaining Mucosal Homeostasis in the Mammalian Large Intestine.

Suryasarathi Dasgupta, Igor Maricic, Jay Tang, Stephen Wandro, Kelly Weldon, Carolina S Carpenter, Lars Eckmann, Jesus Rivera-Nieves, William Sandborn, Rob Knight and 3 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in ImmunoHorizons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Suryasarathi DasguptaDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA.
Igor MaricicDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA.
Jay TangDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA.
Stephen WandroCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA.
Kelly WeldonCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA.
Carolina S CarpenterCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA.
Lars EckmannDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA.ORCID 0000-0002-7987-8742
Jesus Rivera-NievesDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA.
William SandbornDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA.
Rob KnightCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA.
Peter DorresteinCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA.
Austin D SwaffordCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA.
Vipin KumarDivision of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, CA; vckumar@health.ucsd.edu.ORCID 0000-0002-2838-2472
University of California San Diego · USCedars-Sinai Medical Center · US

Funding

San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Novel Traffic-targeted Therapies for IBDR01DK108670 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RIVERA-NIEVES, JESUS · 2016 to 2020
$3.3M
Integrin αEβ7-dependent IgA transcytosis during homeostasis and IBDR01DK132242 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesus Rivera-Nieves · 2022 to 2026
$2.6M
Interplay Among NKT Cell Subsets in Alcoholic Liver DiseaseR01AA020864 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMAR, VIPIN · 2012 to 2016
$1.8M
Regulatory CD4/CD8 T cells in autoimmune demyelinationR01AI052227 · NIAID · TORREY PINES INST FOR MOLECULAR STUDIES · PI KUMAR, VIPIN · 2003 to 2006
$1.4M
A novel population of PLZF+CD8+ regulatory T cells: phenotype and functionR56AI146071 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMAR, VIPIN · 2020 to 2020
$558k
High Dimensional Mass Cytometry Analysis of the Effects of Vedolizumab in Intestinal Cellular Subsets and its Correlation with Clinical ParametersR21DK118927 · NIDDK · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI RIVERA-NIEVES, JESUS · 2019 to 2020
$392k
BLRD VA I01 BX003436BLRD VA I01 BX005951NIAAA NIH HHS R01 AA020864NIAID NIH HHS R01 AI052227NIAID NIH HHS R56 AI146071NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK108670NIDDK NIH HHS R01 DK132242NIDDK NIH HHS R21 DK118927NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

Lymphocytes within the intestinal epithelial layer (IEL) in mammals have unique composition compared with their counterparts in the lamina propria. Little is known about the role of some of the key colonic IEL subsets, such as TCRαβ

Indexed as

Adoptive TransferAnimalsAntigens, CDCD8 AntigensCD8-Positive T-LymphocytesDendritic CellsFemaleHistocompatibility Antigens Class IHomeostasisIntegrin alpha ChainsIntestine, LargeMammalsMiceMice, Inbred C57BLReceptors, Antigen, T-Cell, alpha-betaT-Lymphocytes, Regulatoryalpha E integrinsAntigens, CDCD8 AntigensHistocompatibility Antigens Class IIntegrin alpha ChainsQ surface antigensReceptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID34911745
PMCPMC10026853
OpenAlexW4200537313

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read34
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.