Evidence map›Paper›PMID 34911731›Full record

ArticleClinical journal of the American Society of Nephrology : CJASN2022

Controlled Study of Decision-Making Algorithms for Kidney Replacement Therapy Initiation in Acute Kidney Injury.

Yvelynne P Kelly, Kavita Mistry, Salman Ahmed, Shimon Shaykevich, Sonali Desai, Stuart R Lipsitz, David E Leaf, Ernest I Mandel, Emily Robinson, Gearoid McMahon and 4 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Clinical journal of the American Society of Nephrology : CJASN, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03368183 (Acute Kidney Injury Standardized Clinical Assessment and Management Plan for Renal Replacement Initiation), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03368183 nacompletednot on this map

Acute Kidney Injury Standardized Clinical Assessment and Management Plan for Renal Replacement Initiation

TypeinterventionalSponsorBrigham and Women's HospitalRan2017 to 2022Enrolled224ConditionsAcute Kidney InjuryArmsCare delivery algorithim
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. How to Leverage Implementation Science to Achieve Equity in Nephrology Care Delivery.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Yvelynne P KellyDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-4733-5129
Kavita MistryDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Salman AhmedDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Shimon ShaykevichDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Sonali DesaiDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Stuart R LipsitzDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
David E LeafDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-7875-090
Ernest I MandelDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Emily RobinsonDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Gearoid McMahonDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Peter G CzarneckiDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
David M CharytanNephrology Division, New York University Grossman School of Medicine, New York, New York.ORCID 0000-0002-7695-3583
Sushrut S WaikarSection of Nephrology, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts.ORCID 0000-0003-4004-326
Mallika L MenduDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Brigham and Women's Hospital · USBoston University · USNew York University · US

Funding

Novel signaling pathways in the ciliary inversin compartmentK08DK123400 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI CZARNECKI, PETER G · 2020 to 2024
$893k
NIDDK NIH HHS K08 DK123400
6 · The paper itself

Abstract

BACKGROUND AND

objectivesAKI requiring KRT is associated with high mortality and utilization. We evaluated the use of an AKI Standardized Clinical Assessment and Management Plan (SCAMP) on patient outcomes, including mortality, hospital length of stay, and intensive care unit length of stay. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a 12-month controlled study in the intensive care units of a large academic tertiary medical center. We alternated use of the AKI-SCAMP with use of a "sham" control form in 4- to 6-week blocks. The primary outcome was risk of inpatient mortality. Prespecified secondary outcomes included 30- and 60-day mortality, hospital length of stay, and intensive care unit length of stay. Generalized estimating equations were used to estimate the effect of the AKI-SCAMP on mortality and length of stay.

resultsThere were 122 patients in the AKI-SCAMP group and 102 patients in the control group. There was no significant difference in inpatient mortality associated with AKI-SCAMP use (41% versus 47% control). AKI-SCAMP use was associated with significantly reduced intensive care unit length of stay (mean, 8; 95% confidence interval, 8 to 9 days versus mean, 12; 95% confidence interval, 10 to 13 days;

conclusionsUse of the AKI-SCAMP tool for AKI KRT was not significantly associated with inpatient mortality, but was associated with reduced intensive care unit length of stay, hospital length of stay, and use of KRT in cases of physician-perceived treatment futility. CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: Acute Kidney Injury Standardized Clinical Assessment and Management Plan for Renal Replacement Initiation, NCT03368183. PODCAST: This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2022_02_07_CJN02060221.mp3.

Indexed as

AlgorithmsClinical Decision-MakingRenal Replacement TherapyAcute Kidney InjuryAgedFemaleHumansIntensive Care UnitsLength of StayMaleMiddle AgedTreatment Outcomeacute kidney injuryalgorithmsbiochemical phenomenarenal replacement therapy

Identifiers

PMID34911731
PMCPMC8823944
OpenAlexW4200277113

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.