ArticleBMC pulmonary medicine2021
Clinicopathological characteristics of IgG4-related lung disease.
Article in BMC pulmonary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Pulmonary manifestations, treatments and outcomes of IgG4-related disease-a systematic literature review.Rheumatology international · 2024Pooled it
- Staged traditional Chinese medicine treatment for suspected pulmonary inflammatory pseudotumor with progressive lesion reduction: a case report and literature review.Frontiers in medicine · 2026Article
- CT Chest findings in IgG4-related disease.Annals of medicine · 2025Article
- Clinical characteristics of IgG4-related lung disease: a single-center based experience.Clinical rheumatology · 2025Article
- Pulmonary plasma cell disorders: histopathology, diagnosis, and clinical perspectives.Virchows Archiv : an international journal of pathology · 2025Review
- [Analysis of clinical characteristics and current diagnosis and treatment status of IgG4-related diseases in the real world].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025Article
- Bronchial Obstruction in Immunoglobulin G4-Related Disease.Annals of thoracic surgery short reports · 2025Article
- Clinicopathological features of lacrimal gland biopsy lesions in 582 Chinese patients.Scientific reports · 2024Article
- An overlapping case of IgG4-related disease and systemic lupus erythematosus treated with belimumab: a case-based review.Rheumatology international · 2024Review
- Thoracic manifestations of IgG4-related disease.Respirology (Carlton, Vic.) · 2023Review
- Clinical characteristics of IgG4Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
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Authors and funding
8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundImmunoglobulin G4-related lung disease (IgG4-RLD) is a rare entity. We retrospectively analyzed the clinical and histopathological characteristics of patients with pathologically confirmed IgG4-RLD to improve the diagnosis rate and reduce the risk of misdiagnosis.
methodsWe screened the pathological reports of 4838 patients with pulmonary surgery and/or biopsy specimens from April 2017 to April 2021 at Sun Yat-Sen Memorial Hospital affiliated with Sun Yat-Sen University, and specimens from 65 patients with suspected IgG4-RLD were subjected to immunohistochemical staining for IgG4 and IgG. Finally, 10 patients with definite IgG4-RLD that was pathologically confirmed were enrolled and analyzed.
resultsThe incidence of pathologically confirmed IgG4-RLD was 0.2% (10/4838). The ten patients had an average age of 59.7 years at diagnosis, and the male-to-female ratio was 9:1. The initial clinical manifestations were nonspecific, and cough was the most common symptom (4/10). More than one organ was involved in most patients (8/10), and mediastinal/hilar lymph node involvement was often observed (7/10). Serum IgG4 was analyzed in 6 patients and found to be elevated. Serum tumor marker levels were within the normal range or were slightly elevated. Computed tomography (CT) of the chest and/or
conclusionsThe results of our study suggest that multiple imaging findings, an elevated serum IgG4 concentration, and no significant increase in serum tumor biomarkers could provide diagnostic support for IgG4-RLD, especially for isolated IgG4-RLD or IgG4-RLD that includes other organ involvement that does not aid in establishing the diagnosis.
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