ArticleBMC oral health2021
Periodontitis as a risk for oral cancer: a case-control study.
Article in BMC oral health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06701058 (Active MMP-8 in Oral Fluid for the Detection of Oral and Oropharyngeal Cancer), which is not on this map. Cited by 58 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Active MMP-8 in Oral Fluid for the Detection of Oral and Oropharyngeal Cancer
Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Demystifying the link between periodontitis and oral cancer: a systematic review integrating clinical, pre-clinical, and in vitro data.Cancer metastasis reviews · 2025Pooled it
- Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies.Acta odontologica Scandinavica · 2024Pooled it
- Puerarin alleviates inflammation and promotes osteogenic differentiation in periodontitis: insights from autophagy and Notch signaling pathway.Odontology · 2026Article
- Association of human papillomavirus infection with increased new-onset periodontitis risk: A multi-center retrospective cohort study.Journal of periodontology · 2026Article
- Gingipain-Mediated Matrix Metalloproteinase-8 and -9 Activation in Oral Rinse Samples from Patients with Cancer: A Cross-Sectional Study.Dentistry journal · 2026Article
- Periodontal Disease and Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis of Risk and Survival Outcomes.Journal of clinical medicine · 2026Review
- Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition.FEBS open bio · 2026Article
- Review
- Associations between periodontitis and postoperative infectious complications in OSCC patients: a retrospective study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- WTAP Contributes to Periodontitis Pathogenesis by Promoting PDLSC Senescence and Impairing Osteogenic Differentiation via m6A-Dependent Regulation of TP53BP1.Immunity, inflammation and disease · 2026Article
- Relationship between periodontitis and oral cancer: A Mendelian randomization study.Bioinformation · 2026Article
- Could periodontitis be associated with overall and cancer-specific mortality risk; a 35-year Swedish cohort study.Acta odontologica Scandinavica · 2025Article
- Differences in oral health status between cancer patients: a case-control observational study.BMC oral health · 2025Observational
- Impact of oral anaerobic bacteria on the tumor immune microenvironment and prognosis of oral cancer.Journal of translational medicine · 2025Article
- A community cross-sectional study on oral health status among rural and urban inhabitants of Zambia.Scientific reports · 2025Article
- Association between dental scaling and the lower risk of oral cancer: A population-based nested case-control study.Journal of dental sciences · 2025Article
- Association of Periodontal Disease and Tooth Loss with Cancer in Korean Adults: A Nationwide Cross-Sectional Study.Oral health & preventive dentistry · 2025Article
- Frequency of periodontal disease in head and neck cancer patients after radiation therapy: a cross-sectional study.BMC oral health · 2025Article
- Association of Oral Health Determinants With Oral Squamous Cell Carcinoma in Never-Smoking Adults.Head & neck · 2025Article
- Oral Microbial Dysbiosis Driven by Periodontitis Facilitates Oral Squamous Cell Carcinoma Progression.Cancers · 2025Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aetiology of oral cancer is multifactorial, as various risk factors (genetics, socioeconomic and lifestyle factors) contribute to its development. Data in the literature suggest that people with periodontal disease have an increased risk of developing oral cancer, and the severity of periodontitis correlates with the appearance of oral squamous cell carcinoma. The aim of this study was to revise the non-genetic risk factors that may influence the development of OC, while focusing on the dental and periodontal status and OH.
methodsTwo hundred patients (hundred diagnosed with oral cancer and hundred without oral cancer) were enrolled in our case-control study, to evaluate the association between oral cancer and the presence and severity of periodontitis, while examining several risk factors that might be responsible for oral cancer formation. A questionnaire customised for oral cancer patients was used to obtain the socioeconomic and lifestyle risk factors that may influence the development of oral squamous cell carcinoma. The dental and periodontal status along with the level of oral hygiene was recorded quantitatively. The chi-square and Mann-Whitney tests and logistic regression were used for the statistical analysis.
resultsBy considering both the case and the control groups, a significant correlation was found between the incidence of oral cancer and some socioeconomic factors and lifestyle habits, such as the sex, age, education and alcohol consumption of an individual. The mean value of the Silness-Löe plaque index was significantly higher in the case population. The number of completely edentulous patients was higher among the oral cancer population. The incidence of oral cancer was 57.1% in patients with periodontal disease. In comparison, the incidence of oral squamous cell carcinoma was only 28.6% among the patients without periodontitis. Most of the oral cancer patients (72.1%) had stage 4 periodontitis. On the other hand, the vast majority of the control group (51.6%) had stage 2 periodontitis.
conclusionPeriodontitis can be an individual risk factor for oral cancer development. Periodontally compromised individuals should be strictly monitored, especially those with severe periodontitis and coexisting lifestyle risk factors. Maintaining their periodontal health in at-risk patients can minimize cancer risks.
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