Evidence map›Paper›PMID 34911476›Full record

ArticleBMC ophthalmology2021

Spiroplasma species as a rare cause of congenital cataract and uveitis: a case series.

Navid Farassat, Michael Reich, Annerose Serr, Sebastian Küchlin, Marwa Erwemi, Claudia Auw-Hädrich, Hermann Krastel, Wolf Alexander Lagrèze

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. A human-associatediScience · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Navid FarassatEye Center, Medical Center, Faculty of Medicine, Albert-Ludwig University Freiburg, Killianstraße 5, 79106, Freiburg, Germany. navid.farassat@uniklinik-freiburg.de.ORCID http://orcid.org/0000-0002-4409-2176
Michael ReichEye Center, Medical Center, Faculty of Medicine, Albert-Ludwig University Freiburg, Killianstraße 5, 79106, Freiburg, Germany.
Annerose SerrInstitute for Microbiology and Hygiene, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Sebastian KüchlinEye Center, Medical Center, Faculty of Medicine, Albert-Ludwig University Freiburg, Killianstraße 5, 79106, Freiburg, Germany.
Marwa ErwemiDepartment of Ophthalmology, Medical Faculty Mannheim, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.
Claudia Auw-HädrichEye Center, Medical Center, Faculty of Medicine, Albert-Ludwig University Freiburg, Killianstraße 5, 79106, Freiburg, Germany.
Hermann KrastelDepartment of Ophthalmology, Medical Faculty Mannheim, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.
Wolf Alexander LagrèzeEye Center, Medical Center, Faculty of Medicine, Albert-Ludwig University Freiburg, Killianstraße 5, 79106, Freiburg, Germany.
Heidelberg University · DEUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo date, only four cases of ocular spiroplasma infection have been reported in the entire ophthalmic literature. We add two more cases to raise awareness of this sight-threatening congenital disease that manifests as cataract with ocular inflammation. CASE PRESENTATION: Both infants were referred for cataracts associated with ocular inflammation. Case 1, a 3-week-old neonate presented with unilateral cataract, ocular inflammation and elevated intraocular pressure. Case 2 was a 3-month-old infant with bilateral cataract and panuveitis. Lensectomies with or without vitrectomy and subsequent analyses of the specimens were performed. Transmission electron microscopy and multiplex polymerase chain reaction or 16 s rRNA gene polymerase chain reaction revealed spiroplasma species.

conclusionsSpiroplasma as a very rare cause for congenital cataract might be underdiagnosed. We recommend performing polymerase chain reaction to probe for spiroplasma species in congenital cataracts with an inflammatory component.

Indexed as

CataractCataract ExtractionSpiroplasmaUveitisEyeHumansInfantInfant, NewbornCongenital cataractSpiroplasma ixodetisUveitis

Identifiers

PMID34911476
PMCPMC8672502
OpenAlexW4200005690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.