Evidence map›Paper›PMID 34911255›Full record

ArticleJournal of stroke2022

Long-Term Follow-up of Enhanced Holter-Electrocardiography Monitoring in Acute Ischemic Stroke.

Rolf Wachter, Mark Weber-Krüger, Gerhard F Hamann, Pawel Kermer, Jan Liman, Meinhard Mende, Joachim Seegers, Katrin Wasser, Sonja Gröschel, Timo Uphaus and 8 more

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of stroke, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07553650 (Master Study Protocol for the Cohort of the Specialist Network Stroke), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07553650 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Master Study Protocol for the Cohort of the Specialist Network Stroke (SN Stroke) (Stroke-CORE)

Typeobservational_patient_registrySponsorCharite University, Berlin, GermanyRan2026 to 2030Enrolled12,750ConditionsIntracerebral Haemorrhage, Paediatric Stroke, Stroke Acute, Stroke
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 12 institutions in 2 countries.

Rolf WachterClinic and Policlinic for Cardiology, University Hospital Leipzig, Leipzig, Germany.
Mark Weber-KrügerClinic for Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany.
Gerhard F HamannClinic for Neurology and Neurorehabilitation, Bezirkskrankenhaus Günzburg, Günzburg, Germany.
Pawel KermerClinic for Neurology, Nordwest-Krankenhaus Sanderbusch, Sande, Germany.
Jan LimanClinic for Neurology, University of Göttingen, Göttingen, Germany.
Meinhard MendeCenter for Clinical Trials and Institute for Medical Informatics, Statistics and Epidemiology, University Leipzig, Leipzig, Germany.
Joachim SeegersDivision of Electrophysiology, Department of Internal Medicine II, Klinikum Landshut, Landshut, Germany.
Katrin WasserClinic for Neurology, University of Göttingen, Göttingen, Germany.
Sonja GröschelDepartment of Neurology, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany.
Timo UphausDepartment of Neurology, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany.
Holger PoppertClinic for Neurology, Helios Klinikum München-West, München, Germany.
Martin KöhrmannDepartment of Neurology, University Hospital Essen, Essen, Germany.
Markus ZabelDZHK (German Center for Cardiovascular Research), partner site Göttingen, Göttingen, Germany.
Ulrich LaufsClinic and Policlinic for Cardiology, University Hospital Leipzig, Leipzig, Germany.
Peter U HeuschmannInstitute for Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.
David ConenPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada.
Klaus GröschelDepartment of Neurology, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany.
Find-AFRANDOMISED Investigators and CoordinatorsClinic and Policlinic for Cardiology, University Hospital Leipzig, Leipzig, Germany.
Johannes Gutenberg University Mainz · DEUniversitätsmedizin Göttingen · DEUniversity of Göttingen · DEEssen University Hospital · DEFachkrankenhaus Hubertusburg · DEKrankenhaus Nordwest · DELeipzig University · DEPopulation Health Research Institute · CATUM Klinikum · DEUniversity Hospital Leipzig · DEUniversity of Applied Sciences Landshut · DEUniversity of Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeProlonged electrocardiography (ECG)-monitoring in stroke patients improves the detection of paroxysmal atrial fibrillation (pAF). However, most randomized studies only had short follow-up. We aimed to provide 3-year follow-up data for AF detection and stroke recurrence risk.

methodsWe randomized 402 patients aged ≥60 years with acute ischemic strokes without AF to either enhanced and prolonged monitoring (EPM; 3×10-day Holter-ECG-monitoring) or standard-of-care (≥24 hours ECG-monitoring). The endpoint of the current analysis was AF within 36 months analyzed by intention to treat. Long-term follow-up was performed for 36 months.

resultsTwo hundred and seventy-four patients (80%) participated in the extended follow-up (median duration of follow-up was 36 months [interquartile range, 12 to 36]). During the first 6 months, more AF was documented in the EPM arm compared to the control arm (13.5% vs. 5.1%; 95% confidence interval, 2.9% to 14.4%; P=0.004). During months 6 to 36, AF was less detected in the EPM intervention arm than in the control arm (2.0% vs. 7.3%; 95% confidence interval, 0.7% to 9.9%; P=0.028). Overall, the detection rate of AF within 36 months was numerically higher within the EPM group (15.0% vs. 11.1%, P=0.30). Numerically less patients in the EPM arm had recurrent ischemic strokes (5.5% vs. 9.1%, P=0.18), transient ischemic attacks (3.0% vs. 4.5%, P=0.44) or died (4.5% vs. 6.6%, P=0.37).

conclusionsEnhanced and prolonged ECG monitoring increased AF detection during the first six months, but there was significantly more clinical AF during months 6 to 36 observed in the usual-care arm. This suggests that EPM leads to an earlier detection of clinically relevant AF.

Indexed as

Atrial fibrillationElectrocardiographic monitoringRandomized controlled trialStroke

Identifiers

PMID34911255
PMCPMC8829482
OpenAlexW4200412813

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.