ArticleNeuroImage. Clinical2021
Resting-state network topology characterizing callous-unemotional traits in adolescence.
Article in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- A comprehensive systematic review of fMRI studies on brain connectivity in healthy children and adolescents: Current insights and future directions.Developmental cognitive neuroscience · 2024Pooled it
- Affective theory of mind impairments linked with callous-unemotional traits implicate cognitive control: A pre-registered double-blind randomized controlled trial with a dual-task paradigm.Journal of affective disorders · 2025Trial
- Aberrant Resting-State Functional Connectivity Associated With Callous-Unemotional Traits From Late Childhood Through Late Adolescence.Biological psychiatry global open science · 2026Article
- Alterations in Region-Specific Gray Matter Volume Underlying Callous Unemotional Traits in Adolescents.Brain and behavior · 2025Article
- Atypical functional connectome is associated with low reflective functioning in incarcerated adolescents.Frontiers in psychiatry · 2024Article
- Executive function and underlying brain network distinctions for callous-unemotional traits and conduct problems in adolescents.bioRxiv : the preprint server for biology · 2023Article
- Efficiency of Heterogenous Functional Connectomes Explains Variance in Callous-Unemotional Traits After Computational Lesioning of Cortical Midline and Salience Regions.Brain connectivity · 2023Article
- Connectome-based predictive modeling of empathy in adolescents with and without the low-prosocial emotion specifier.Neuroscience letters · 2023Article
- Cognitive Mechanisms Underlying Prosocial Decision Making in Callous-Unemotional Traits.Journal of psychopathology and behavioral assessment · 2023Article
- Resting-state connectivity underlying cognitive control's association with perspective taking in callous-unemotional traits.Psychiatry research. Neuroimaging · 2023Article
- Psychopathic traits and altered resting-state functional connectivity in incarcerated adolescent girls.Frontiers in neuroimaging · 2023Article
- Associated functional network connectivity between callous-unemotionality and cognitive and affective empathy.Journal of affective disorders · 2022Article
- Callous-unemotional traits in adolescents moderate neural network associations with empathy.Psychiatry research. Neuroimaging · 2022Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCallous-unemotional (CU) traits, a youth antisocial phenotype, are hypothesized to associate with aberrant connectivity (dis-integration) across the salience (SAL), default mode (DMN), and frontoparietal (FPN) networks. However, CU traits have a heterogeneous presentation and previous research has not modeled individual heterogeneity in resting-state connectivity amongst adolescents with CU traits. The present study models individual-specific network maps and examines topological features of individual and subgroup maps in relation to CU traits.
methodsParticipants aged 13-17 (n = 84, male = 55%, female = 45%) completed resting-state functional connectivity and the inventory of callous-unemotional traits as part of the Nathan Klein Rockland study. A sparse network approach (GIMME) was used to derive individual-level and subgroup maps of all participants. We then examined heterogeneous network features, including positive and negative connection density, associated with CU traits.
resultsHigher rates of CU traits increased probability of inclusion in one subgroup, which had the highest mean level of CU traits. Analysis of network features reveals less density (positive and negative) within the FPN and greater density between DMN-FPN associated with CU traits. DISCUSSION: Findings indicate heterogeneous person-specific connections and some subgroup connections amongst adolescents associate with CU traits. Higher CU traits associate with lower density in the FPN, which has been associated with attention and inhibition, and higher density between the DMN-FPN, which have been linked with cognitive control, social working memory, and empathy. Our findings suggest less efficiency in FPN function which, when considered mechanistically, could result in difficulty suppressing DMN when task positive networks are engaged. This is an area for further exploration but could explain cognitive and socio-affective impairments in CU traits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.