ArticleCurrent biology : CB2022
Retinal horizontal cells use different synaptic sites for global feedforward and local feedback signaling.
Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Bipolar cell networks underlying steady-state intensity encoding in intrinsically photosensitive retinal ganglion cells.iScience · 2026Article
- Rod photoreceptors control the ON vs OFF polarity of cone-signaling neurons.Communications biology · 2026Article
- Decoding the roles of bipolar, amacrine, and horizontal cells.Handbook of clinical neurology · 2026Review
- S-cone-specific circuitry in the outer plexiform layer of a cone-dominant mammal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Adaptations to hypoxia in the vertebrate retina.The Journal of physiology · 2025Review
- Retinal Neurochemistry.Brain sciences · 2025Review
- Horizontal cell connectivity in the anchovy retina-a 3D electron microscopic study.BMC biology · 2025Article
- Morphology and connectivity of retinal horizontal cells in two avian species.Frontiers in cellular neuroscience · 2025Article
- The first interneuron of the mouse visual system is tailored to the natural environment through morphology and electrical coupling.iScience · 2024Article
- The sodium-bicarbonate cotransporter Slc4a5 mediates feedback at the first synapse of vision.Neuron · 2024Article
- Retinoic Acid-Dependent Loss of Synaptic Output from Bipolar Cells Impairs Visual Information Processing in Inherited Retinal Degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cellular Characterization and Interspecies Evolution of the Tree Shrew Retina across Postnatal Lifespan.Research (Washington, D.C.) · 2024Article
- Investigation of heterocellular features of the mouse retinal neurovascular unit by 3D electron microscopy.Journal of anatomy · 2023Article
- Amacrine cells differentially balance zebrafish color circuits in the central and peripheral retina.Cell reports · 2023Article
- Super-resolution STED imaging in the inner and outer whole-mount mouse retina.Frontiers in ophthalmology · 2023Article
- Sustained deep-tissue voltage recording using a fast indicator evolved for two-photon microscopy.Cell · 2022Article
- Review
- Visual processing: When two synaptic strata are better than one.Current biology : CB · 2022Article
- The RNA-binding protein and stress granule component ATAXIN-2 is expressed in mouse and human tissues associated with glaucoma pathogenesis.The Journal of comparative neurology · 2022Article
- Spectral inference reveals principal cone-integration rules of the zebrafish inner retina.Current biology : CB · 2021Article
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Authors and funding
18 authors at 6 institutions in 2 countries.
Funding
Abstract
In the outer plexiform layer (OPL) of the mammalian retina, cone photoreceptors (cones) provide input to more than a dozen types of cone bipolar cells (CBCs). In the mouse, this transmission is modulated by a single horizontal cell (HC) type. HCs perform global signaling within their laterally coupled network but also provide local, cone-specific feedback. However, it is unknown how HCs provide local feedback to cones at the same time as global forward signaling to CBCs and where the underlying synapses are located. To assess how HCs simultaneously perform different modes of signaling, we reconstructed the dendritic trees of five HCs as well as cone axon terminals and CBC dendrites in a serial block-face electron microscopy volume and analyzed their connectivity. In addition to the fine HC dendritic tips invaginating cone axon terminals, we also identified "bulbs," short segments of increased dendritic diameter on the primary dendrites of HCs. These bulbs are in an OPL stratum well below the cone axon terminal base and make contacts with other HCs and CBCs. Our results from immunolabeling, electron microscopy, and glutamate imaging suggest that HC bulbs represent GABAergic synapses that do not receive any direct photoreceptor input. Together, our data suggest the existence of two synaptic strata in the mouse OPL, spatially separating cone-specific feedback and feedforward signaling to CBCs. A biophysical model of a HC dendritic branch and voltage imaging support the hypothesis that this spatial arrangement of synaptic contacts allows for simultaneous local feedback and global feedforward signaling by HCs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.