Evidence map›Paper›PMID 34910919›Full record

ArticleCell reports2021

Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation.

Jun Li, Beisi Xu, Minghong He, Xinying Zong, Trevor Cunningham, Cher Sha, Yiping Fan, Richard Cross, Jacob H Hanna, Yongqiang Feng

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 38 citations in OpenAlex.

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  3. Rag1-based time-stamp tracing of T-cell developmental origins.Journal of immunology (Baltimore, Md. : 1950) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Jun LiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Beisi XuCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Minghong HeDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Xinying ZongDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Trevor CunninghamDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Cher ShaDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Yiping FanCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Richard CrossDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jacob H HannaDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Yongqiang FengDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: Yong.Feng@stjude.org.
St. Jude Children's Research Hospital · USWeizmann Institute of Science · IL

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Robust immune tolerance conferred by Foxp3 transcriptional regulationR01AI153138 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI FENG, YONGQIANG · 2021 to 2025
$2.2M
A novel genetic tool to investigate T cell development and functionR21AI146614 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI FENG, YONGQIANG · 2019 to 2020
$494k
NCI NIH HHS P30 CA021765NIAID NIH HHS R01 AI153138NIAID NIH HHS R21 AI146614
6 · The paper itself

Abstract

Regulatory T (T

Indexed as

DNA DemethylationGene Expression RegulationAcetylationAnimalsCell DifferentiationDNA-Binding ProteinsDNA MethylationFemaleForkhead Transcription FactorsHistonesMaleMiceMice, Inbred C57BLMice, KnockoutPromoter Regions, GeneticProto-Oncogene ProteinsDNA-Binding ProteinsForkhead Transcription FactorsFoxp3 protein, mouseHistonesProto-Oncogene ProteinsTET1 protein, mousecell fateDNA demethylationFoxp3histone acetylationregulatory T cellstranscription

Identifiers

PMID34910919
PMCPMC8711072
OpenAlexW4200049454

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.