ArticleCell reports2021
The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition.
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Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
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Who cites it
23 citing papers in PubMed.
- tRNA mEMBO reports · 2026Article
- Flow-Induced Yap/Taz Signaling Balances Endothelial and Hematopoietic Stem Cell Fates.bioRxiv : the preprint server for biology · 2026Article
- Fetal-restricted hematopoietic progenitors arise from hemogenic endothelium in vitelline and umbilical arteries.Nature cardiovascular research · 2026Article
- Mechanometabolism instructs hematopoietic stem cell specification.The Journal of experimental medicine · 2026Article
- Blood Flow Regulates Metabolism in Hematopoietic Development.Advances in experimental medicine and biology · 2026Review
- Microglial Extracellular Vesicles Mediate C1q Deposition at the Pre-Synapse and Promote Synaptic Pruning.Journal of extracellular vesicles · 2025Article
- Single-cell profiling reveals three endothelial-to-hematopoietic transitions with divergent isoform expression landscapes.Nature cardiovascular research · 2025Article
- CBKMR: A Copula-based Bayesian Kernel Machine Regression Framework for Optimal Marker Detection in Omics Data.bioRxiv : the preprint server for biology · 2025Article
- CD43, but not CD41 or GPI-80, marks first definitive haematopoietic stem cells in the human embryo.Development (Cambridge, England) · 2025Article
- Article
- Glycolytic state of aortic endothelium favors hematopoietic transition during the emergence of definitive hematopoiesis.Science advances · 2024Article
- Null mutation of exocyst complex component 3-like does not affect vascular development in mice.Experimental animals · 2024Article
- Haematopoietic development and HSC formation in vitro: promise and limitations of gastruloid models.Emerging topics in life sciences · 2023Review
- The genesis of human hematopoietic stem cells.Blood · 2023Article
- Hematopoietic Stem Cell (HSC)-Independent Progenitors Are Susceptible to Mll-Af9-Induced Leukemic Transformation.Cancers · 2023Article
- Single-Cell RNA Sequencing of Sox17-Expressing Lineages Reveals Distinct Gene Regulatory Networks and Dynamic Developmental Trajectories.Stem cells (Dayton, Ohio) · 2023Article
- Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition.Nature communications · 2023Article
- De Novo Generation of Human Hematopoietic Stem Cells from Pluripotent Stem Cells for Cellular Therapy.Cells · 2023Review
- Lessons from early life: understanding development to expand stem cells and treat cancers.Development (Cambridge, England) · 2022Review
- KIT is dispensable for physiological organ vascularisation in the embryo.Angiogenesis · 2022Article
Corrections and comments
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Authors and funding
19 authors.
Emanuele AzzoniMRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK. Electronic address: emanuele.azzoni@unimib.it.
Vincent FronteraMRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Giorgio AnselmiMRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Christina RodeMRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Chela JamesDepartment of Cancer Biology, UCL Cancer Institute, University College London, London, WC1E 6DD, UK.
Elitza M DeltchevaDepartment of Cancer Biology, UCL Cancer Institute, University College London, London, WC1E 6DD, UK.
Atanasiu S DemianMRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
John BrownDepartment of Cancer Biology, UCL Cancer Institute, University College London, London, WC1E 6DD, UK.
Cristiana BaroneSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, 20900, Italy.
Arianna PatelliSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, 20900, Italy.
Joe R HarmanMRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Matthew NichollsMRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Simon J ConwayHB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, IN 46033, USA.
Edward MorrisseyMRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Sten Eirik W JacobsenMRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK; Hematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK; Department of Cell and Molecular Biology, Wallenberg Institute for Regenerative Medicine and Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet and Karolinska University Hospital, 171 77 Stockholm, Sweden.
Duncan B SparrowDepartment of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford, Oxford, OX1 3PT, UK.
Adrian L HarrisDepartment of Oncology, Molecular Oncology Laboratories, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.
Tariq EnverDepartment of Cancer Biology, UCL Cancer Institute, University College London, London, WC1E 6DD, UK; Division of Molecular Medicine and Gene Therapy, Lund University, Lund, 22184, Sweden.
Marella F T R de BruijnMRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK. Electronic address: marella.debruijn@imm.ox.ac.uk.
Funding
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3MTwo-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6MImmuno-Oncology Translation Network: Data Management and Resource-Sharing Center at RPCIU24CA232979 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI HUTSON, ALAN DAVID, LIU, SONG · 2018 to 2024
$8.9MCancer Research UK 18974Medical Research Council G0501838Medical Research Council G0801073Medical Research Council G0902418Medical Research Council MC_UU_00016/2Medical Research Council MC_UU_00016/5Medical Research Council MC_UU_12009/2Medical Research Council MC_UU_12009/5NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA016058NCI NIH HHS U24 CA232979
Abstract
Hematopoietic stem cells (HSCs) emerge during development from the vascular wall of the main embryonic arteries. The onset of circulation triggers several processes that provide critical external factors for HSC generation. Nevertheless, it is not fully understood how and when the onset of circulation affects HSC emergence. Here we show that in Ncx1
Indexed as
Cell DifferentiationCell LineageGlycolysisHematopoiesisAnimalsEndothelium, VascularFemaleHematopoietic Stem CellsMiceMice, Inbred C57BLMice, KnockoutOxidative PhosphorylationSingle-Cell AnalysisSodium-Calcium ExchangerTranscriptomeNCX1 protein, mouseSodium-Calcium Exchanger
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.