Evidence map›Paper›PMID 34910894›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022

High-resolution relaxometry-based calibrated fMRI in murine brain: Metabolic differences between awake and anesthetized states.

Mengyang Xu, Binshi Bo, Mengchao Pei, Yuyan Chen, Christina Y Shu, Qikai Qin, Lydiane Hirschler, Jan M Warnking, Emmanuel L Barbier, Zhiliang Wei and 6 more

Open access · greenAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Where do we stand on fMRI in awake mice?Cerebral cortex (New York, N.Y. : 1991) · 2024
    Pooled it
  3. Preclinical in-vivo cerebrovascular imaging in rodent models: Methods and applications in Alzheimer's disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  4. Article
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  11. Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  12. Article
  13. Mapping oxidative metabolism in the human brain with calibrated fMRI in health and disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 4 countries.

Mengyang XuiHuman Institute, ShanghaiTech University, Shanghai, China.ORCID 0000-0003-1346-1191
Binshi BoCAS Center for Excellence in Brain Sciences and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China.
Mengchao PeiCAS Center for Excellence in Brain Sciences and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China.
Yuyan ChenCAS Center for Excellence in Brain Sciences and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China.
Christina Y ShuBiomedical Engineering, Yale University, New Haven, CT, USA.
Qikai QiniHuman Institute, ShanghaiTech University, Shanghai, China.ORCID 0000-0002-8826-5171
Lydiane HirschlerGrenoble Institut des Neurosciences, Inserm, Univ. Grenoble Alpes, Grenoble, France.ORCID 0000-0003-2379-0861
Jan M WarnkingGrenoble Institut des Neurosciences, Inserm, Univ. Grenoble Alpes, Grenoble, France.ORCID 0000-0002-1683-5163
Emmanuel L BarbierGrenoble Institut des Neurosciences, Inserm, Univ. Grenoble Alpes, Grenoble, France.
Zhiliang WeiRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Hanzhang LuRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-3871-1564
Peter HermanMagnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA.
Fahmeed HyderBiomedical Engineering, Yale University, New Haven, CT, USA.
Zhi-Jie LiuiHuman Institute, ShanghaiTech University, Shanghai, China.
Zhifeng LiangCAS Center for Excellence in Brain Sciences and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China.
Garth J ThompsoniHuman Institute, ShanghaiTech University, Shanghai, China.
Chinese Academy of Sciences · CNInserm · FRYale University · USKennedy Krieger Institute · USShanghaiTech University · CN

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Energetics of Neuronal Populations by fMRIR01MH067528 · NIMH · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED · 2002 to 2021
$5.9M
Understanding evoked and resting-state fMRI through multi scale imagingR01MH111424 · NIMH · YALE UNIVERSITY · PI CONSTABLE, R TODD, CRAIR, MICHAEL C. · 2016 to 2020
$5.2M
Multimodal flavor integration and retronasal olfaction in the mouseR01DC014723 · NIDCD · JOHN B. PIERCE LABORATORY, INC. · PI VERHAGEN, JUSTUS V. · 2016 to 2020
$2.4M
MRS validation of computational metabolic modeling of human brain function to determine energetic disruptions underlying fMRI-derived functional connectivity in degenerative or psychiatric disordersR01NS100106 · NINDS · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED, ROTHMAN, DOUGLAS LYLE · 2017 to 2021
$959k
NCATS NIH HHS UL1 TR001863NIDCD NIH HHS R01 DC014723NIMH NIH HHS R01 MH067528NIMH NIH HHS R01 MH111424NINDS NIH HHS R01 NS100106
6 · The paper itself

Abstract

Functional magnetic resonance imaging (fMRI) techniques using the blood-oxygen level-dependent (BOLD) signal have shown great potential as clinical biomarkers of disease. Thus, using these techniques in preclinical rodent models is an urgent need. Calibrated fMRI is a promising technique that can provide high-resolution mapping of cerebral oxygen metabolism (CMR

Indexed as

Magnetic Resonance ImagingWakefulnessAnimalsBrainBrain MappingCerebrovascular CirculationMiceOxygenOxygen ConsumptionOxygenanesthesiaAwake micecalibrated fMRICMRO2dexmedetomidinepCASLTRUST

Identifiers

PMID34910894
PMCPMC9014688
OpenAlexW4200279639

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.