Evidence map›Paper›PMID 34910775›Full record

ArticlePloS one2021

Synthesis and evaluation of radiogallium-labeled long-chain fatty acid derivatives as myocardial metabolic imaging agents.

Nurmaya Effendi, Kenji Mishiro, Hiroshi Wakabayashi, Malwina Gabryel-Skrodzka, Kazuhiro Shiba, Junichi Taki, Renata Jastrząb, Seigo Kinuya, Kazuma Ogawa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Nurmaya EffendiInstitute for Frontier Science Initiative, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, Japan.
Kenji MishiroInstitute for Frontier Science Initiative, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, Japan.
Hiroshi WakabayashiDepartment of Nuclear Medicine, Kanazawa University Hospital, Kanazawa University, Takara-machi, Kanazawa, Ishikawa, Japan.
Malwina Gabryel-SkrodzkaFaculty of Chemistry, Adam Mickiewicz University in Poznan, Poznan, Poland.
Kazuhiro ShibaResearch Center for Experimental Modeling of Human Disease, Kanazawa University, Takara-machi, Kanazawa, Ishikawa, Japan.
Junichi TakiDepartment of Nuclear Medicine, Kanazawa University Hospital, Kanazawa University, Takara-machi, Kanazawa, Ishikawa, Japan.
Renata JastrząbFaculty of Chemistry, Adam Mickiewicz University in Poznan, Poznan, Poland.ORCID 0000-0002-7989-5083
Seigo KinuyaDepartment of Nuclear Medicine, Kanazawa University Hospital, Kanazawa University, Takara-machi, Kanazawa, Ishikawa, Japan.
Kazuma OgawaInstitute for Frontier Science Initiative, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, Japan.ORCID 0000-0002-1691-7302
Kanazawa University · JPKanazawa University Hospital · JPAdam Mickiewicz University in Poznań · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since long-chain fatty acids work as the primary energy source for the myocardium, radiolabeled long-chain fatty acids play an important role as imaging agents to diagnose metabolic heart dysfunction and heart diseases. With the aim of developing radiogallium-labeled fatty acids, herein four fatty acid-based tracers, [67Ga]Ga-HBED-CC-PDA, [67Ga]Ga-HBED-CC-MHDA, [67Ga]Ga-DOTA-PDA, and [67Ga]Ga-DOTA-MHDA, which are [67Ga]Ga-HBED-CC and [67Ga]Ga-DOTA conjugated with pentadecanoic acid (PDA) and 3-methylhexadecanoic acid (MHDA), were synthesized, and their potential for myocardial metabolic imaging was evaluated. Those tracers were found to be chemically stable in 0.1 M phosphate buffered saline. Initial [67Ga]Ga-HBED-CC-PDA, [67Ga]Ga-HBED-CC-MHDA, [67Ga]Ga-DOTA-PDA, and [67Ga]Ga-DOTA-MHDA uptakes in the heart at 0.5 min postinjection were 5.01 ± 0.30%ID/g, 5.74 ± 1.02%ID/g, 5.67 ± 0.22%ID/g, and 5.29 ± 0.10%ID/g, respectively. These values were significantly lower than that of [123I]BMIPP (21.36 ± 2.73%ID/g). For their clinical application as myocardial metabolic imaging agents, further structural modifications are required to increase their uptake in the heart.

Indexed as

AnimalsCell Line, TumorEdetic AcidFatty AcidsGalliumGallium RadioisotopesHeartHeterocyclic Compounds, 1-RingHumansJapanMaleMiceMyocardiumPositron-Emission TomographyRadioisotopesTissue Distribution1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidEdetic AcidFatty AcidsGalliumGallium-67Gallium RadioisotopesHeterocyclic Compounds, 1-RingN,N'-bis(2-hydroxy-5-(ethylene-beta-carboxy)benzyl)ethylenediamine N,N'-diacetic acidRadioisotopes

Identifiers

PMID34910775
PMCPMC8673672
OpenAlexW4200320875

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.