Evidence map›Paper›PMID 34910759›Full record

ArticlePloS one2021

Implications of OPRM1 and CYP2B6 variants on treatment outcomes in methadone-maintained patients in Ontario: Exploring sex differences.

Caroul Chawar, Alannah Hillmer, Amel Lamri, Flavio Kapczinski, Lehana Thabane, Guillaume Pare, Zainab Samaan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Influence ofLife (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Caroul ChawarNeuroscience Graduate Program, McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-8935-5454
Alannah HillmerNeuroscience Graduate Program, McMaster University, Hamilton, ON, Canada.
Amel LamriDepartment of Medicine, McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-7182-0661
Flavio KapczinskiDepartment of Psychiatry and Behavioural Neurosciences, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Lehana ThabanePopulation Health Research Institute, Hamilton, ON, Canada.
Guillaume ParePopulation Health Research Institute, Hamilton, ON, Canada.
Zainab SamaanDepartment of Psychiatry and Behavioural Neurosciences, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
St. Joseph’s Healthcare Hamilton · CAPopulation Health Research Institute · CA

Funding

CIHR PJT-156306
6 · The paper itself

Abstract

Genetic variants in the OPRM1 and CYP2B6 genes, respectively coding for an opioid receptor and methadone metabolizers, have been linked to negative treatment outcomes in patients undergoing methadone maintenance treatment, with little consensus on their effect. This study aims to test the associations between pre-selected SNPs of OPRM1 and CYP2B6 and outcomes of continued opioid use, relapse, and methadone dose. It also aims to observe differences in associations within the sexes. 1,172 participants treated with methadone (nMale = 666, nFemale = 506) were included in this study. SNPs rs73568641 and rs7451325 from OPRM1 and all the tested CYP2B6 SNPs were detected to be in high linkage disequilibrium. Though no associations were found to be significant, noteworthy differences were observed in associations of OPRM1 rs73568641 and CYP2B6 rs3745274 with treatment outcomes between males and females. Further research is needed to determine if sex-specific differences are present.

Indexed as

AdultAllelesAnalgesics, OpioidCytochrome P-450 CYP2B6FemaleGene FrequencyGenotypeHumansLinkage DisequilibriumMaleMethadoneOntarioOpiate Substitution TreatmentOpioid-Related DisordersPolymorphism, Single NucleotideReceptors, Opioid, muAnalgesics, OpioidCYP2B6 protein, humanCytochrome P-450 CYP2B6MethadoneOPRM1 protein, humanReceptors, Opioid, mu

Identifiers

PMID34910759
PMCPMC8673616
OpenAlexW4200323493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.