ArticleeLife2021
Emergence and function of cortical offset responses in sound termination detection.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Data-Constrained Recurrent Network Neural Model Uncovers the Circuit Mechanism of Olfactory OFF Responses.bioRxiv : the preprint server for biology · 2026Article
- Computing the effects of excitatory-inhibitory balance on neuronal input-output properties.PLoS computational biology · 2026Article
- Neural Response Reliability as a Marker of the Transition of Neural Codes along Auditory Pathways.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The what, which, when, why and who of Off responses in the auditory system.The Journal of physiology · 2025Review
- Parvalbumin neurons and cortical coding of dynamic stimuli: a network model.Journal of neurophysiology · 2025Article
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- Functional MRI reveals subcortical auditory push-pull interactions requiring intercollicular integrity.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- A general model unifying the adaptive, transient and sustained properties of ON and OFF auditory neural responses.PLoS computational biology · 2024Article
- Mixed Representations of Sound and Action in the Auditory Midbrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Topography and Ensemble Activity in the Auditory Cortex of a Mouse Model of Fragile X Syndrome.eNeuro · 2024Article
- Auditory Corticofugal Neurons Transmit Auditory and Non-auditory Information During Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Distinct topographic organization and network activity patterns of corticocollicular neurons within layer 5 auditory cortex.Frontiers in neural circuits · 2023Article
- Offset Responses in the Auditory Cortex Show Unique History Dependence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Decoding violated sensory expectations from the auditory cortex of anaesthetised mice: Hierarchical recurrent neural network depicts separate 'danger' and 'safety' units.The European journal of neuroscience · 2022Article
- More than the end: OFF response plasticity as a mnemonic signature of a sound's behavioral salience.Frontiers in computational neuroscience · 2022Review
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Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Offset responses in auditory processing appear after a sound terminates. They arise in neuronal circuits within the peripheral auditory system, but their role in the central auditory system remains unknown. Here, we ask what the behavioral relevance of cortical offset responses is and what circuit mechanisms drive them. At the perceptual level, our results reveal that experimentally minimizing auditory cortical offset responses decreases the mouse performance to detect sound termination, assigning a behavioral role to offset responses. By combining in vivo electrophysiology in the auditory cortex and thalamus of awake mice, we also demonstrate that cortical offset responses are not only inherited from the periphery but also amplified and generated de novo. Finally, we show that offset responses code more than silence, including relevant changes in sound trajectories. Together, our results reveal the importance of cortical offset responses in encoding sound termination and detecting changes within temporally discontinuous sounds crucial for speech and vocalization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.