Evidence map›Paper›PMID 34910590›Full record

ArticleJCO global oncology2021

International Socioeconomic Predictors of Colon and Rectal Cancer Mortality: Is Colorectal Cancer a First World Problem?

Christina L Cui, Anna M Dornisch, Anya E Umlauf, Raphael E Cuomo, James D Murphy, Nicole E Lopez

Open access · goldAbstract read
In one paragraph

Article in JCO global oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. A CLRN3-Based CD8Biomolecules · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Christina L CuiDepartment of Surgery, Duke University, Durham, NC.ORCID 0000-0002-1525-8499
Anna M DornischUniversity of California, San Diego School of Medicine, La Jolla, CA.
Anya E UmlaufDepartment of Psychiatry, University of California, San Diego, San Diego, CA.ORCID 0000-0003-2005-6071
Raphael E CuomoDepartment of Anesthesiology, University of California, San Diego, La Jolla, CA.ORCID 0000-0002-8179-0619
James D MurphyDepartment of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, CA.ORCID 0000-0002-0523-9091
Nicole E LopezDivision of Colon and Rectal Surgery, Department of Surgery, University of California, San Diego, La Jolla, CA.ORCID 0000-0002-4807-7360
University of California San Diego · USDuke University · US

Funding

San Diego Biomedical Informatics Education & Research (SABER)T15LM011271 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHAMIM NEMATI · 2012 to 2026
$9.7M
UC San Diego Clinical and Translational Research InstituteTL1TR001443 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2019
$3.4M
NCATS NIH HHS TL1 TR001443NLM NIH HHS T15 LM011271
6 · The paper itself

Abstract

purposeColorectal cancer (CRC) is a leading cause of international morbidity and is the second highest cause of cancer-related mortality in the world. The purpose of this study was to investigate the relationship between international health care spending on CRC mortality over time.

methodsThis is a retrospective study using a publicly available data from the WHO Global Health Observatory database. General estimating equations were used to analyze the relationship between total health care expenditure per capita (THEpc) and CRC mortality at the country level. The primary predictors of interest were quartiles of THEpc. Other exposure variables included gross domestic product per capita (GDPpc), smoking (% of adult population smoking), physician density (per 10,000), and time.

resultsMortality decreased significantly from 2000 to 2016 (coefficient [95% CI], -2.2 [-3.3 to -1.1];

conclusionOverall, mortality decreased significantly over the study period. Countries with higher health expenditures and higher gross domestic products experienced higher rates of CRC mortality. Further research will be necessary to determine the cause for this, but we postulate that it may be a result of more robust diagnostic and follow-up methods in countries with more resources.

Indexed as

Colorectal NeoplasmsRectal NeoplasmsAdultHumansRetrospective StudiesSocioeconomic Factors

Identifiers

PMID34910590
PMCPMC8691512
OpenAlexW4200564443

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.