Evidence map›Paper›PMID 34910577›Full record

ReviewEcoSal Plus2021

Localization, Assembly, and Activation of the Escherichia coli Cell Division Machinery.

Petra Anne Levin, Anuradha Janakiraman

Open access · greenAbstract readReview
In one paragraph

Review in EcoSal Plus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 53 citations in OpenAlex.

  1. Review
  2. Defining the order of assembly of theJournal of bacteriology · 2026
    Article
  3. Devising a divisome for synthetic cells.Nature reviews. Chemistry · 2026
    Review
  4. Article
  5. Article
  6. Defining the order of assembly of thebioRxiv : the preprint server for biology · 2026
    Article
  7. Dysregulation of a nucleotidyltransferase induces division and surface glycan defects inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Journal of bacteriology · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Petra Anne LevinDepartment of Biology, Washington University in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0003-2071-0547
Anuradha JanakiramanDepartment of Biology, The City College of New York, New York, New York, USA.ORCID 0000-0002-7487-0178
The Graduate Center, CUNY · USWashington University in St. Louis · US

Funding

HOMEOSTATIC CONTROL OF BACTERIAL GROWTH AND CELL DIVISIONR35GM127331 · NIGMS · WASHINGTON UNIVERSITY · PI Petra Anne Levin · 2018 to 2026
$4.3M
NIGMS NIH HHS R35 GM127331
6 · The paper itself

Abstract

Decades of research, much of it in Escherichia coli, have yielded a wealth of insight into bacterial cell division. Here, we provide an overview of the E. coli division machinery with an emphasis on recent findings. We begin with a short historical perspective into the discovery of FtsZ, the tubulin homolog that is essential for division in bacteria and archaea. We then discuss assembly of the divisome, an FtsZ-dependent multiprotein platform, at the midcell septal site. Not simply a scaffold, the dynamic properties of polymeric FtsZ ensure the efficient and uniform synthesis of septal peptidoglycan. Next, we describe the remodeling of the cell wall, invagination of the cell envelope, and disassembly of the division apparatus culminating in scission of the mother cell into two daughter cells. We conclude this review by highlighting some of the open questions in the cell division field, emphasizing that much remains to be discovered, even in an organism as extensively studied as E. coli.

Indexed as

Escherichia coliEscherichia coli ProteinsBacterial ProteinsCell DivisionCytoskeletal ProteinsBacterial ProteinsCytoskeletal ProteinsEscherichia coli Proteinscell divisiondivisomeEscherichia coliFtsZpeptidoglycan

Identifiers

PMID34910577
PMCPMC8919703
OpenAlexW4200275467

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.