Evidence map›Paper›PMID 34910553›Full record

Observational studyJCO global oncology2021

Trends in Breast Cancer Mortality Between 2001 and 2017: An Observational Study in the European Union and the United Kingdom.

Chinmay Jani, Ingrid Salcicciol, Arashdeep Rupal, Omar Al Omari, Richard Goodall, Justin D Salciccioli, Dominic C Marshall, Georgina Hanbury, Harpreet Singh, Lisa Weissmann and 1 more

Erratum issuedAbstract readObservational Study
In one paragraph

Observational study in JCO global oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trends in male breast cancer in Spain, 1999-2023: a nationwide analysis of incidence and mortality.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  2. Mapping the invisible: a Bayesian spatio-temporal analysis of male breast cancer mortality inequalities across Spanish provinces, 1999-2023.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  3. Early- versus late-onset mortality trends in breast and female genital cancers in Spain, 1999-2024.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Chinmay JaniDepartment of Medicine, Mount Auburn Hospital/Beth Israel Lahey Health, Cambridge, MA.ORCID 0000-0002-6917-5568
Ingrid SalcicciolHarvard T H School of Public Health, Boston, MA.ORCID 0000-0002-3645-3795
Arashdeep RupalDepartment of Medicine, Mount Auburn Hospital/Beth Israel Lahey Health, Cambridge, MA.ORCID 0000-0001-7261-2338
Omar Al OmariDepartment of Medicine, Mount Auburn Hospital/Beth Israel Lahey Health, Cambridge, MA.
Richard GoodallDepartment of Surgery and Cancer, Imperial College of London, London, United Kingdom.
Justin D SalciccioliHarvard Medical School, Boston, MA.ORCID 0000-0001-8092-0883
Dominic C MarshallNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0002-3498-2511
Georgina HanburyDepartment of Surgery and Cancer, Imperial College of London, London, United Kingdom.
Harpreet SinghDepartment of Medicine, Mount Auburn Hospital/Beth Israel Lahey Health, Cambridge, MA.ORCID 0000-0002-8001-4191
Lisa WeissmannDepartment of Medicine, Mount Auburn Hospital/Beth Israel Lahey Health, Cambridge, MA.
Joseph ShalhoubDepartment of Surgery and Cancer, Imperial College of London, London, United Kingdom.ORCID 0000-0003-1011-7440

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBreast cancer is the most common cancer in women worldwide, representing 25.4% of the newly diagnosed cases in 2018. The past two decades have seen advancements in screening technologies, guidelines, and newer modalities of treatment. Our study reports and compares trends in breast cancer mortality in the European Union and the United Kingdom. MATERIALS AND

methodsWe used the WHO Mortality Database. We extracted breast cancer mortality data from 2001 to 2017 on the basis of the International Classification of Diseases, 10th revision system. Crude mortality rates were dichotomized by sex and reported by year. We computed age-standardized death rates (ASDRs) per 100,000 population using the world standard population. Breast cancer mortality trends were compared using joinpoint regression analysis.

resultsWe analyzed data from 24 EU countries, including the United Kingdom. For women, breast cancer mortality was observed to be downtrending in all countries except Croatia, France, and Poland. For the most recent female data, the highest ASDR for breast cancer was identified in Croatia (19.29 per 100,000), and the lowest ASDR was noted in Spain (12.8 per 100,000). Denmark had the highest change in ASDR and the highest estimated annual percentage change of -3.2%. For men, breast cancer mortality decreased in 18 countries, with the largest relative reduction observed in Denmark with an estimated annual percentage change of -27.5%. For the most recent male data, the highest ASDR for breast cancer was identified in Latvia (0.54 per 100,000).

conclusionBreast cancer mortality rates have down trended in most EU countries between 2001 and 2017 for both men and women. Given the observational nature of this study, causality to the observed trends cannot be reliably ascribed. However, possible contributing factors should be considered and subject to further study.

Indexed as

Breast NeoplasmsDatabases, FactualEuropean UnionFemaleHumansMaleRegression AnalysisUnited Kingdom

Identifiers

PMID34910553
PMCPMC8691519

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.