ArticleScience translational medicine2021
A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques.
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Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
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31 citing papers in PubMed, 59 citations in OpenAlex.
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- Emerging nanomedicine for liver diseases treatment.Journal of nanobiotechnology · 2025Review
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- The Pathogenic Role of T Cell Metabolism and its Effect on Immune Senescence in Autoimmune Diseases and Infection.Clinical reviews in allergy & immunology · 2025Review
- Ferroptosis as a key player in the pathogenesis and intervention therapy in liver injury: focusing on drug-induced hepatotoxicity.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Arachidonic acid metabolism in metabolic dysfunction-associated steatotic liver disease and liver fibrosis.Hepatology communications · 2025Review
- The Role of Ferroptosis in Women's Health and Diseases.MedComm · 2025Review
- Current Therapeutic Landscape for Metabolic Dysfunction-Associated Steatohepatitis.International journal of molecular sciences · 2025Review
- Metabolism of hepatic stellate cells in chronic liver diseases: emerging molecular and therapeutic interventions.Theranostics · 2025Review
- Ferulic acid inhibits lipogenesis and ameliorates MASLD via targeting PGC-1β.Frontiers in nutrition · 2025Article
- Altered drug metabolism and increased susceptibility to fatty liver disease in a mouse model of myotonic dystrophy.Nature communications · 2024Article
- Protein posttranslational modifications in metabolic diseases: basic concepts and targeted therapies.MedComm · 2024Review
- Potential therapeutic strategies for MASH: from preclinical to clinical development.Life metabolism · 2024Review
- Ferroptosis: Biology and Role in Gastrointestinal Disease.Gastroenterology · 2024Review
- Targeting ketone body metabolism to treat fatty liver disease.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2024Review
- Targeting ferroptosis opens new avenues for the development of novel therapeutics.Signal transduction and targeted therapy · 2023Review
- Icariin Supplementation Suppresses the Markers of Ferroptosis and Attenuates the Progression of Nonalcoholic Steatohepatitis in Mice Fed a Methionine Choline-Deficient Diet.International journal of molecular sciences · 2023Article
- The role of lipid metabolism in cancer radioresistance.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023Review
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Authors and funding
35 authors at 9 institutions in 4 countries.
Xiao-Jing ZhangDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.ORCID 0000-0002-8271-7405
Yan-Xiao JiInstitute of Model Animal of Wuhan University, Wuhan 430071, China.ORCID 0000-0002-3401-2427
Xu ChengDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.ORCID 0000-0002-1577-7627
Yanjie ChengInstitute of Model Animal of Wuhan University, Wuhan 430071, China.ORCID 0000-0001-7684-8946
Hailong YangDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Junyong WangDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.ORCID 0000-0002-7799-4555
Ling-Ping ZhaoInstitute of Model Animal of Wuhan University, Wuhan 430071, China.
Yong-Ping HuangInstitute of Model Animal of Wuhan University, Wuhan 430071, China.ORCID 0000-0003-3663-6521
Dating SunDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.ORCID 0000-0001-6504-4985
Hui XiangDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.ORCID 0000-0001-9910-697X
Li-Jun ShenDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.ORCID 0000-0002-8132-2890
Peng-Long LiInstitute of Model Animal of Wuhan University, Wuhan 430071, China.ORCID 0000-0001-8522-7893
Jun-Peng MaInstitute of Model Animal of Wuhan University, Wuhan 430071, China.ORCID 0000-0002-6533-2386
Rui-Feng TianDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.ORCID 0000-0003-2827-6941
Juan YangDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Xinxin YaoInstitute of Model Animal of Wuhan University, Wuhan 430071, China.
Haibo XuDepartment of Radiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.ORCID 0000-0002-8451-8979
Rufang LiaoDepartment of Radiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Li XiaoDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Peng ZhangInstitute of Model Animal of Wuhan University, Wuhan 430071, China.
Xin ZhangInstitute of Model Animal of Wuhan University, Wuhan 430071, China.
Guang-Nian ZhaoInstitute of Model Animal of Wuhan University, Wuhan 430071, China.ORCID 0000-0002-3112-7595
Xi WangDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Man-Li HuInstitute of Model Animal of Wuhan University, Wuhan 430071, China.ORCID 0000-0001-8318-0454
Song TianDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.ORCID 0000-0002-7006-6588
Juan WanDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.ORCID 0000-0003-4869-2459
Jingjing CaiDepartment of Cardiology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.ORCID 0000-0002-7820-536X
Xinliang MaDepartment of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19004, USA.ORCID 0000-0002-9041-0876
Qingbo XuCentre for Clinic Pharmacology, The William Harvey Research Institute, Queen Mary University of London, London SE5 9NU, UK.ORCID 0000-0003-2474-8155
Yibin WangDepartment of Anesthesiology, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-0852-0767
Rhian M TouyzBritish Heart Foundation Chair in Cardiovascular Medicine, and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK.ORCID 0000-0003-0670-0887
Peter P LiuDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada.ORCID 0000-0002-3017-1199
Rohit LoombaNAFLD Research Center, Division of Gastroenterology and Epidemiology, University of California, San Diego, San Diego, CA 92093, USA.ORCID 0000-0002-4845-9991
Zhi-Gang SheDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.ORCID 0000-0001-9402-4166
Hongliang LiDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.ORCID 0000-0002-9821-0297
Wuhan University · CNBritish Heart Foundation · GBCentral South University · CNQueen Mary University of London · GBThomas Jefferson University · USUniversity of California, Los Angeles · USUniversity of California San Diego · USUniversity of Ottawa · CAWuhan Union Hospital · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonalcoholic steatohepatitis (NASH) is a progressive liver disease and has become a leading indication for liver transplantation in the United States. The development of effective therapies for NASH is a major unmet need. Here, we identified a small molecule, IMA-1, that can treat NASH by interrupting the arachidonate 12-lipoxygenase (ALOX12)–acetyl-CoA carboxylase 1 (ACC1) interaction. IMA-1 markedly blocked diet-induced NASH progression in both male mice and
Indexed as
Non-alcoholic Fatty Liver DiseaseAcetyl-CoA CarboxylaseAnimalsLiverMacacaMaleMiceMice, Inbred C57BLACC1 protein, mouseAcetyl-CoA Carboxylase
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