Evidence map›Paper›PMID 34910547›Full record

ArticleScience translational medicine2021

β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development.

Shuyun Rao, Xiaochun Yang, Kazufumi Ohshiro, Sobia Zaidi, Zhanhuai Wang, Kirti Shetty, Xiyan Xiang, Md Imtaiyaz Hassan, Taj Mohammad, Patricia S Latham and 14 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
  2. Review
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  4. Serum Proteomic Profile Based on the TGF-β Pathway Stratifies Risk of Hepatocellular Carcinoma.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  5. Review
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  8. Review
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  14. Review
  15. Article
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  18. Dietary fat and lipid metabolism in the tumor microenvironment.Biochimica et biophysica acta. Reviews on cancer · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 12 institutions in 5 countries.

Shuyun RaoInstitute for Bioelectronic Medicine, Feinstein Institutes for Medical Research; Divisions of Gastroenterology and Hepatology, Department of Medicine, Northwell Health, Manhasset, NY 11030, USA.ORCID 0000-0002-1073-6682
Xiaochun YangInstitute for Bioelectronic Medicine, Feinstein Institutes for Medical Research; Divisions of Gastroenterology and Hepatology, Department of Medicine, Northwell Health, Manhasset, NY 11030, USA.ORCID 0000-0002-7026-8809
Kazufumi OhshiroInstitute for Bioelectronic Medicine, Feinstein Institutes for Medical Research; Divisions of Gastroenterology and Hepatology, Department of Medicine, Northwell Health, Manhasset, NY 11030, USA.ORCID 0000-0002-5162-5612
Sobia ZaidiInstitute for Bioelectronic Medicine, Feinstein Institutes for Medical Research; Divisions of Gastroenterology and Hepatology, Department of Medicine, Northwell Health, Manhasset, NY 11030, USA.
Zhanhuai WangCenter for Translational Medicine, Department of Surgery, George Washington University, Washington DC 20037, USA.ORCID 0000-0003-0154-394X
Kirti ShettyDivision of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Xiyan XiangInstitute for Bioelectronic Medicine, Feinstein Institutes for Medical Research; Divisions of Gastroenterology and Hepatology, Department of Medicine, Northwell Health, Manhasset, NY 11030, USA.ORCID 0000-0002-4746-9522
Md Imtaiyaz HassanCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.ORCID 0000-0002-3663-4940
Taj MohammadCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.ORCID 0000-0002-0399-4835
Patricia S LathamCenter for Translational Medicine, Department of Surgery, George Washington University, Washington DC 20037, USA.ORCID 0000-0003-2782-9444
Bao-Ngoc NguyenCenter for Translational Medicine, Department of Surgery, George Washington University, Washington DC 20037, USA.
Linda WongCancer Biology Department, University of Hawaii Cancer Center, HI 96813, USA.ORCID 0000-0003-3143-5384
Herbert YuEpidemiology Program, University of Hawaii Cancer Center, HI 96813, USA.ORCID 0000-0003-3950-4815
Yousef Al-AbedInstitute for Bioelectronic Medicine, Feinstein Institutes for Medical Research; Divisions of Gastroenterology and Hepatology, Department of Medicine, Northwell Health, Manhasset, NY 11030, USA.
Bibhuti MishraInstitute for Bioelectronic Medicine, Feinstein Institutes for Medical Research; Divisions of Gastroenterology and Hepatology, Department of Medicine, Northwell Health, Manhasset, NY 11030, USA.ORCID 0000-0001-5302-2447
Michele VaccaTVPLab, Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.ORCID 0000-0002-1973-224X
Gareth GuenigaultCN Bio Innovations Limited, Cambridge CB4 0WH, UK.ORCID 0000-0002-0294-8677
Michael E D AllisonLiver Unit, Cambridge Biomedical Research Centre, Cambridge University Hospitals, Cambridge CB2 0QQ, UK.ORCID 0000-0003-3677-3294
Antonio Vidal-PuigTVPLab, Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.ORCID 0000-0003-4220-9577
Jihane N BenhammouVatche and Tamar Manoukian Division of Digestive Diseases and Gastroenterology, Hepatology and Parenteral Nutrition, David Geffen School of Medicine at UCLA and VA Greater Los Angeles HCS, Los Angeles, CA 90095, USA.ORCID 0000-0003-2442-5145
Marcus AlvarezDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Päivi PajukantaDepartment of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Joseph R PisegnaDepartment of Medicine and Human Genetics, Division of Gastroenterology, Hepatology and Parenteral Nutrition, David Geffen School of Medicine at UCLA and VA Greater Los Angeles HCS, Los Angeles, CA 90095, USA.ORCID 0000-0002-5442-2474
Lopa MishraInstitute for Bioelectronic Medicine, Feinstein Institutes for Medical Research; Divisions of Gastroenterology and Hepatology, Department of Medicine, Northwell Health, Manhasset, NY 11030, USA.
Feinstein Institute for Medical Research · USGeorge Washington University · USUniversity of California, Los Angeles · USJamia Millia Islamia · INUniversity of Hawaiʻi at Mānoa · USCN Bio Innovations (United Kingdom) · GBNorthwell Health · USUniversity of Cambridge · GBUniversity of Maryland, Baltimore · USVA Greater Los Angeles Healthcare System · USWellcome/MRC Institute of Metabolic Science · GBWellcome Sanger Institute · GB

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Role of Beta Spectrin and Smad in Alcohol-Induced Liver and GI Cell ProliferationR01AA023146 · NIAAA · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Lopa Mishra · 2013 to 2026
$4.6M
Pathway Specific Functional Biomarkers for the Early Detection of Liver CancerU01CA230690 · NCI · GEORGE WASHINGTON UNIVERSITY · PI MISHRA, LOPA, SHETTY, KIRTI · 2018 to 2022
$3.4M
Cellular interactions between TGF-beta pathway members and epignetic regulators in liver and gastrointestinal cancersR01CA236591 · NCI · GEORGE WASHINGTON UNIVERSITY · PI Jian Chen, Lopa Mishra · 2018 to 2026
$3.0M
BLRD VA I01 BX003732Medical Research Council G0400192Medical Research Council G0802051Medical Research Council MC_UU_00014/2Medical Research Council MC_UU_12012/2Medical Research Council MC_UU_12012/5NCI NIH HHS R01 CA236591NCI NIH HHS U01 CA230690NIAAA NIH HHS R01 AA023146NIDDK NIH HHS P30 DK041301
6 · The paper itself

Abstract

The prevalence of nonalcoholic steatohepatitis (NASH) and liver cancer is increasing. De novo lipogenesis and fibrosis contribute to disease progression and cancerous transformation. Here, we found that β2-spectrin (SPTBN1) promotes sterol regulatory element (SRE)–binding protein (SREBP)–stimulated lipogenesis and development of liver cancer in mice fed a high-fat diet (HFD) or a western diet (WD). Either hepatocyte-specific knockout of SPTBN1 or siRNA-mediated therapy protected mice from HFD/WD-induced obesity and fibrosis, lipid accumulation, and tissue damage in the liver. Biochemical analysis suggested that HFD/WD induces SPTBN1 and SREBP1 cleavage by CASPASE-3 and that the cleaved products interact to promote expression of genes with sterol response elements. Analysis of human NASH tissue revealed increased

Indexed as

NeoplasmsNon-alcoholic Fatty Liver DiseaseAnimalsDiet, High-FatLiverMiceMice, Inbred C57BLSpectrinSpectrin

Identifiers

PMID34910547
PMCPMC8941321
OpenAlexW4200005010

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.