Evidence map›Paper›PMID 34910498›Full record

ArticleJournal of natural products2022

Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from

Neda Safa, Tomaž Trobec, Darren C Holland, Blazej Slazak, Erik Jacobsson, Jeffrey A Hawkes, Robert Frangež, Kristina Sepčić, Ulf Göransson, Lindon W K Moodie and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural products, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Neda SafaPharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Centre, Uppsala University, 75237 Uppsala, Sweden.
Tomaž TrobecInstitute of Preclinical Sciences, Veterinary Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.
Darren C HollandSchool of Environment and Science, Griffith University, Southport 4222, Gold Coast, Australia.ORCID 0000-0002-2498-6084
Blazej SlazakPharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Centre, Uppsala University, 75237 Uppsala, Sweden.ORCID 0000-0002-4143-6543
Erik JacobssonPharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Centre, Uppsala University, 75237 Uppsala, Sweden.ORCID 0000-0001-9508-008X
Jeffrey A HawkesAnalytical Chemistry, Department of Chemistry, Biomedical Centre, Uppsala University, 75120 Uppsala, Sweden.ORCID 0000-0003-0664-2242
Robert FrangežInstitute of Preclinical Sciences, Veterinary Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.
Kristina SepčićDepartment of Biology, Biotechnical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.
Ulf GöranssonPharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Centre, Uppsala University, 75237 Uppsala, Sweden.ORCID 0000-0002-5005-9612
Lindon W K MoodieDrug Design and Discovery, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University, 75123 Uppsala, Sweden.ORCID 0000-0002-9500-4535
Luke P RobertsonPharmacognosy, Department of Pharmaceutical Biosciences, Biomedical Centre, Uppsala University, 75237 Uppsala, Sweden.ORCID 0000-0001-5987-2426
Uppsala University · SEUniversity of Ljubljana · SIGriffith University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During a research program to identify new cholinesterase inhibitors of natural origin, two new 7,8-didehydroprotoberberine alkaloids (

Indexed as

AnimalsBerberine AlkaloidsCholinesterase InhibitorsHumansPapaverSpectrometry, Mass, Electrospray IonizationBerberine AlkaloidsCholinesterase Inhibitorsprotoberberine

Identifiers

PMID34910498
PMCPMC8805119
OpenAlexW4200118174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.