Evidence map›Paper›PMID 34910260›Full record

ReviewBrain informatics2021

Methods for inferring neural circuit interactions and neuromodulation from local field potential and electroencephalogram measures.

Pablo Martínez-Cañada, Shahryar Noei, Stefano Panzeri

Abstract readReview
In one paragraph

Review in Brain informatics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. A Python toolbox for neural circuit parameter inference.NPJ systems biology and applications · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pablo Martínez-CañadaNeural Computation Laboratory, Istituto Italiano Di Tecnologia, Genova and Rovereto, Italy.
Shahryar NoeiNeural Computation Laboratory, Istituto Italiano Di Tecnologia, Genova and Rovereto, Italy.
Stefano PanzeriNeural Computation Laboratory, Istituto Italiano Di Tecnologia, Genova and Rovereto, Italy. stefano.panzeri@gmail.com.ORCID http://orcid.org/0000-0003-1700-8909

Funding

Readout and control of spatiotemporal neuronal codes for behaviorU19NS107464 · NINDS · UNIVERSITY OF CHICAGO · PI KANOLD, PATRICK O · 2018 to 2022
$17.3M
Studying perceptual decision-making across cortex by combining population imaging, connectomics, and computational modelingR01NS108410 · NINDS · HARVARD MEDICAL SCHOOL · PI HARVEY, CHRISTOPHER D, LEE, WEI-CHUNG ALLEN · 2018 to 2022
$5.7M
NIH HHS NS108410NIH HHS U19NS107464NINDS NIH HHS R01 NS108410
6 · The paper itself

Abstract

Electrical recordings of neural mass activity, such as local field potentials (LFPs) and electroencephalograms (EEGs), have been instrumental in studying brain function. However, these aggregate signals lack cellular resolution and thus are not easy to be interpreted directly in terms of parameters of neural microcircuits. Developing tools for a reliable estimation of key neural parameters from these signals, such as the interaction between excitation and inhibition or the level of neuromodulation, is important for both neuroscientific and clinical applications. Over the years, we have developed tools based on neural network modeling and computational analysis of empirical data to estimate neural parameters from aggregate neural signals. This review article gives an overview of the main computational tools that we have developed and employed to invert LFPs and EEGs in terms of circuit-level neural phenomena, and outlines future challenges and directions for future research.

Indexed as

Electroencephalogram (EEG)Information theoryLeaky integrate-and-fire (LIF) neuron modelLocal field potential (LFP)Neural network modelNeural oscillationNeuromodulation

Identifiers

PMID34910260
PMCPMC8674171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.