Evidence map›Paper›PMID 34910246›Full record

ReviewCellular and molecular life sciences : CMLS2021

Hypothalamic inflammation in metabolic disorders and aging.

Anup Bhusal, Md Habibur Rahman, Kyoungho Suk

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 55 citations in OpenAlex.

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  14. TonEBP as a key regulator of hypothalamic leptin signaling and resistance.Cellular and molecular life sciences : CMLS · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Anup BhusalDepartment of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.
Md Habibur RahmanDepartment of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.
Kyoungho SukDepartment of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea. ksuk@knu.ac.kr.ORCID http://orcid.org/0000-0002-9555-4203
Kyungpook National University · KRJohnson University · US

Funding

National Research Foundation of Korea 2016M3C7A1904148National Research Foundation of Korea 2018R1A2A1A05077118National Research Foundation of Korea NRF-2017R1A5A2015391National Research Foundation of Korea NRF-2020M3E5D9079764
6 · The paper itself

Abstract

The hypothalamus is a critical brain region for the regulation of energy homeostasis. Over the years, studies on energy metabolism primarily focused on the neuronal component of the hypothalamus. Studies have recently uncovered the vital role of glial cells as an additional player in energy balance regulation. However, their inflammatory activation under metabolic stress condition contributes to various metabolic diseases. The recruitment of monocytes and macrophages in the hypothalamus helps sustain such inflammation and worsens the disease state. Neurons were found to actively participate in hypothalamic inflammatory response by transmitting signals to the surrounding non-neuronal cells. This activation of different cell types in the hypothalamus leads to chronic, low-grade inflammation, impairing energy balance and contributing to defective feeding habits, thermogenesis, and insulin and leptin signaling, eventually leading to metabolic disorders (i.e., diabetes, obesity, and hypertension). The hypothalamus is also responsible for the causation of systemic aging under metabolic stress. A better understanding of the multiple factors contributing to hypothalamic inflammation, the role of the different hypothalamic cells, and their crosstalks may help identify new therapeutic targets. In this review, we focus on the role of glial cells in establishing a cause-effect relationship between hypothalamic inflammation and the development of metabolic diseases. We also cover the role of other cell types and discuss the possibilities and challenges of targeting hypothalamic inflammation as a valid therapeutic approach.

Indexed as

AgingAnimalsDisease Models, AnimalHumansHypothalamusInflammationMetabolic DiseasesModels, BiologicalAgingDiabetesHypertensionHypothalamusInflammationObesity

Identifiers

PMID34910246
PMCPMC11071926
OpenAlexW4200491842

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.