Evidence map›Paper›PMID 34910220›Full record

ArticleActa neuropathologica2022

Activating NTRK2 and ALK receptor tyrosine kinase fusions extend the molecular spectrum of pleomorphic xanthoastrocytomas of early childhood: a diagnostic overlap with infant-type hemispheric glioma.

Calixto-Hope G Lucas, Zied Abdullaev, Carol S Bruggers, Kanish Mirchia, Nicholas S Whipple, Mouied M Alashari, Amy Lowichik, Samuel Cheshier, Joanna J Phillips, Patrick Devine and 4 more

Abstract readCase ReportsLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Calixto-Hope G LucasDivision of Neuropathology, Department of Pathology, University of California, 505 Parnassus Avenue, Room M551, San Francisco, CA, 94143, USA.ORCID 0000-0002-8347-9592
Zied AbdullaevLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Carol S BruggersDivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.
Kanish MirchiaDivision of Neuropathology, Department of Pathology, University of California, 505 Parnassus Avenue, Room M551, San Francisco, CA, 94143, USA.
Nicholas S WhippleDivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.
Mouied M AlashariDivision of Pediatric Pathology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Amy LowichikDivision of Pediatric Pathology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Samuel CheshierDivision of Pediatric Neurosurgery, Department of Neurosurgery, University of Utah, Salt Lake City, UT, USA.
Joanna J PhillipsDivision of Neuropathology, Department of Pathology, University of California, 505 Parnassus Avenue, Room M551, San Francisco, CA, 94143, USA.
Patrick DevineClinical Cancer Genomics Laboratory, University of California, San Francisco, CA, USA.
David A SolomonDivision of Neuropathology, Department of Pathology, University of California, 505 Parnassus Avenue, Room M551, San Francisco, CA, 94143, USA.
Martha QuezadoLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Kenneth D AldapeLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Arie PerryDivision of Neuropathology, Department of Pathology, University of California, 505 Parnassus Avenue, Room M551, San Francisco, CA, 94143, USA. arie.perry@ucsf.edu.ORCID 0000-0002-8300-7261

Funding

Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4M
Training Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6M
Genomic Biomarkers of CancerZIABC011850 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ALDAPE, KENNETH · 2019 to 2025
$5.1M
Cohesin gene mutations in tumorigenesisDP5OD021403 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SOLOMON, DAVID A. · 2015 to 2019
$2.0M
NCI NIH HHS P50 CA097257NCI NIH HHS T32 CA151022NIH HHS DP5 OD021403
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anaplastic Lymphoma KinaseAstrocytomaBrain NeoplasmsChild, PreschoolFemaleHumansMaleMembrane GlycoproteinsOncogene Proteins, FusionReceptor, trkBALK protein, humanAnaplastic Lymphoma KinaseMembrane GlycoproteinsOncogene Proteins, FusionReceptor, trkBtropomyosin-related kinase-B, human

Identifiers

PMID34910220
PMCPMC8742815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.