ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021
Ultrasound-Guided Minimally Invasive Tissue Sampling: A Minimally Invasive Autopsy Strategy During the COVID-19 Pandemic in Brazil, 2020.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Standardization of minimally invasive tissue sampling (MITS) technique for intestinal sampling in neonatal autopsies.Forensic science, medicine, and pathology · 2026Article
- Mast cells release DNA Extracellular Traps (DETs) in response to SARS-CoV-2 and its spike protein.Cell communication and signaling : CCS · 2026Article
- Rationale and Design of the MIA Trial: A Proof-of-Concept Study of Minimally Invasive Autopsy in an Infectious Cause of Death in a Scandinavian ICU Setting.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026Review
- Post-mortem ultrasound study of coronary circulation on ex-situ hearts.International journal of legal medicine · 2026Article
- Accelerating Proficiency in Minimally Invasive Autopsy for Infectious Disease Diagnosis and Research: A Strategic Framework.Revista da Sociedade Brasileira de Medicina Tropical · 2026Observational
- Percutaneous core needle biopsy guided by ultrasound: a narrative review.Journal of ultrasound · 2025Review
- Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population.Nature medicine · 2024Article
- Histopathological impact of SARS-CoV-2 on the liver: Cellular damage and long-term complications.World journal of gastroenterology · 2024Review
- [Interdisciplinary ultrasound-guided, minimally invasive autopsy in COVID-19-deceased patients in the intensive care unit of a university hospital : A proof-of-concept study].Pathologie (Heidelberg, Germany) · 2023Review
- Minimally invasive autopsies for the investigation of pulmonary pathology of COVID-19-experiences of a longitudinal series of 92 patients.Virchows Archiv : an international journal of pathology · 2023Article
- Younger age is associated with cardiovascular pathological phenotype of severe COVID-19 at autopsy.Frontiers in medicine · 2023Article
- Minimally Invasive Tissue Sampling Surveillance Alliance-Facilitating the Expansion of Pathology-Based Mortality Surveillance.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
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18 authors at 3 institutions in 1 country.
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Abstract
backgroundMinimally invasive autopsies, also known as minimally invasive tissue sampling (MITS), have proven to be an alternative to complete diagnostic autopsies (CDAs) in places or situations where this procedure cannot be performed. During the coronavirus disease 2019 (COVID-19) pandemic, CDAs were suspended by March 2020 in Brazil to reduce biohazard. To contribute to the understanding of COVID-19 pathology, we have conducted ultrasound (US)-guided MITS as a strategy.
methodsThis case series study includes 80 autopsies performed in patients with COVID-19 confirmed by laboratorial tests. Different organs were sampled using a standardized MITS protocol. Tissues were submitted to histopathological analysis as well as immunohistochemical and molecular analysis and electron microscopy in selected cases.
resultsUS-guided MITS proved to be a safe and highly accurate procedure; none of the personnel were infected, and accuracy ranged from 69.1% for kidney, up to 90.1% for lungs, and reaching 98.7% and 97.5% for liver and heart, respectively. US-guided MITS provided a systemic view of the disease, describing the most common pathological findings and identifying viral and other infectious agents using ancillary techniques, and also allowed COVID-19 diagnosis confirmation in 5% of the cases that were negative in premortem and postmortem nasopharyngeal/oropharyngeal swab real-time reverse-transcription polymerase chain reaction.
conclusionsOur data showed that US-guided MITS has the capacity similar to CDA not only to identify but also to characterize emergent diseases.
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