Evidence map›Paper›PMID 34909735›Full record

ReviewJID innovations : skin science from molecules to population health2021

Seeing through the Skin: Photoacoustic Tomography of Skin Vasculature and Beyond.

Daiwei Li, Lucas Humayun, Emelina Vienneau, Tri Vu, Junjie Yao

Open access · goldAbstract readReview
In one paragraph

Review in JID innovations : skin science from molecules to population health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Review
  7. Advances in Photoacoustic Imaging of Breast Cancer.Sensors (Basel, Switzerland) · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. The potential of x-ray virtual histology in the diagnosis of skin tumors.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Quantitative analysis of age-related changes in vascular structure, oxygen saturation, and epidermal melanin structure using photoacoustic methods.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
  17. Article
  18. Relevance and utility of theBiomedical optics express · 2023
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Daiwei LiPhotoacoustic Imaging Lab, Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Lucas HumayunPhotoacoustic Imaging Lab, Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Emelina VienneauPhotoacoustic Imaging Lab, Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Tri VuPhotoacoustic Imaging Lab, Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Junjie YaoPhotoacoustic Imaging Lab, Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Duke University · US

Funding

High-resolution High-speed Photoacoustic and Ultrasound Imaging of SmallVessel Functions in Ischemic StrokeR01NS111039 · NINDS · DUKE UNIVERSITY · PI YAO, JUNJIE · 2019 to 2023
$2.7M
Whole-organ bioreactor with integrated nondestructive 3D molecular imagingR44HL138185 · NHLBI · SONOVOL, INC. · PI CZERNUSZEWICZ, TOMASZ JOSEPH, GESSNER, RYAN · 2017 to 2020
$2.2M
Head-mounted Photoacoustic Imaging of Deep-brain Neural Activities in Freely Behaving AnimalsRF1NS115581 · NINDS · DUKE UNIVERSITY · PI VERKHUSHA, VLADISLAV, YAO, JUNJIE · 2020 to 2020
$2.0M
High-Throughput Volumetric Photoacoustic Imaging of Living Vascularized OrganoidsR01EB028143 · NIBIB · DUKE UNIVERSITY · PI YAO, JUNJIE · 2019 to 2022
$2.0M
Handheld Wound Analyzer for in situ HealingR01GM134036 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, Y. SHRIKE · 2020 to 2023
$1.4M
Transcranial Photoacoustic Imaging Using a Virtual ArrayR21EB027981 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI JING, YUN · 2020 to 2020
$455k
Photoacoustic-imaging-guided intravascular sonothrombolysisR21EB027304 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI JIANG, XIAONING, YAO, JUNJIE · 2019 to 2020
$411k
A turnkey research platform to accelerate clinical translation of focused-ultrasound (FUS) oncology therapiesR43CA239830 · NCI · SONOVOL, INC. · PI GESSNER, RYAN · 2019 to 2019
$300k
Development of a Longitudinal Molecular Imaging Platform to Support Immuno-Oncology ResearchR43CA243822 · NCI · SONOVOL, INC. · PI GESSNER, RYAN · 2019 to 2019
$244k
NCI NIH HHS R43 CA239830NCI NIH HHS R43 CA243822NHLBI NIH HHS R44 HL138185NIBIB NIH HHS R01 EB028143NIBIB NIH HHS R21 EB027304NIBIB NIH HHS R21 EB027981NIGMS NIH HHS R01 GM134036NINDS NIH HHS R01 NS111039NINDS NIH HHS RF1 NS115581
6 · The paper itself

Abstract

Skin diseases are the most common human diseases and manifest in distinct structural and functional changes to skin tissue components such as basal cells, vasculature, and pigmentation. Although biopsy is the standard practice for skin disease diagnosis, it is not sufficient to provide in vivo status of the skin and highly depends on the timing of diagnosis. Noninvasive imaging technologies that can provide structural and functional tissue information in real time would be invaluable for skin disease diagnosis and treatment evaluation. Among the modern medical imaging technologies, photoacoustic (PA) tomography (PAT) shows great promise as an emerging optical imaging modality with high spatial resolution, high imaging speed, deep penetration depth, rich contrast, and inherent sensitivity to functional and molecular information. Over the last decade, PAT has undergone an explosion in technical development and biomedical applications. Particularly, PAT has attracted increasing attention in skin disease diagnosis, providing structural, functional, metabolic, molecular, and histological information. In this concise review, we introduce the principles and imaging capability of various PA skin imaging technologies. We highlight the representative applications in the past decade with a focus on imaging skin vasculature and melanoma. We also envision the critical technical developments necessary to further accelerate the translation of PAT technologies to fundamental skin research and clinical impacts.

Indexed as

ACD, allergy contact dermatitisAR-PAM, acoustic-resolution photoacoustic microscopyCSC, cryogen spray coolingCSVV, cutaneous small-vessel vasculitisCTC, circulating tumor cellFDA, Food and Drug AdministrationNIR, near-infraredOR-PAM, optical-resolution photoacoustic microscopyPACT, photoacoustic computed tomographyPAM, photoacoustic microscopyPA, photoacousticPAT, photoacoustic tomographyPWS, port-wine stainRSOM, raster-scan optoacoustic mesoscopysO2, oxygen saturation of hemoglobinTHb, total hemoglobin concentration

Identifiers

PMID34909735
PMCPMC8659408
OpenAlexW3174588965

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.