Evidence map›Paper›PMID 34909730›Full record

ArticleJID innovations : skin science from molecules to population health2021

Peroxisomal Fatty Acid Oxidation and Glycolysis Are Triggered in Mouse Models of Lesional Atopic Dermatitis.

Petra Pavel, Géraldine Leman, Martin Hermann, Christian Ploner, Thomas O Eichmann, Deborah Minzaghi, Franz P W Radner, Barbara Del Frari, Robert Gruber, Sandrine Dubrac

Open access · goldAbstract read
In one paragraph

Article in JID innovations : skin science from molecules to population health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  10. Article
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  12. Article
  13. The circadian metabolome of atopic dermatitis.The Journal of allergy and clinical immunology · 2024
    Article
  14. The peroxisome: an update on mysteries 3.0.Histochemistry and cell biology · 2024
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Revisiting the Roles of Filaggrin in Atopic Dermatitis.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Petra PavelDepartment of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria.
Géraldine LemanDepartment of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria.
Martin HermannKMT Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Center for Operative Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Christian PlonerDepartment of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Thomas O EichmannInstitute of Molecular Biosciences, University of Graz, Graz, Austria.
Deborah MinzaghiDepartment of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria.
Franz P W RadnerInstitute of Molecular Biosciences, University of Graz, Graz, Austria.
Barbara Del FrariDepartment of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Robert GruberDepartment of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria.
Sandrine DubracDepartment of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria.
Innsbruck Medical University · ATUniversity of Graz · AT

Funding

Austrian Science Fund FWF P 31662Austrian Science Fund FWF P 32225
6 · The paper itself

Abstract

Alterations of the lipid profile of the stratum corneum have an important role in the pathogenesis of atopic dermatitis (AD) because they contribute to epidermal barrier impairment. However, they have not previously been envisioned as a cellular response to altered metabolic requirements in AD epidermis. In this study, we report that the lipid composition in the epidermis of flaky tail, that is,

Indexed as

AD, atopic dermatitisADL, lesional atopic dermatitisATP, adenosine triphosphateCer, ceramideCoA, coenzyme AFA, fatty acidFFA, free fatty acidHEE, human epidermal equivalentIMQ, imiquimodKC, keratinocyteKO, knockoutLB, lamellar bodyPPAR, peroxisome proliferator–activated receptorSC, stratum corneumTEWL, transepidermal water lossULCFA, ultra long-chain fatty acidVLCFA, very-long-chain fatty acid

Identifiers

PMID34909730
PMCPMC8659757
OpenAlexW3171750785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.