Evidence map›Paper›PMID 34909724›Full record

ArticleJID innovations : skin science from molecules to population health2021

MC5R Contributes to Sensitivity to UVB Waves and Barrier Function in Mouse Epidermis.

Akari Shintani, Hiromi Sakata-Haga, Keiichi Moriguchi, Mitsuhiro Tomosugi, Daisuke Sakai, Tsuyoshi Tsukada, Makoto Taniguchi, Masahide Asano, Hiroki Shimada, Hiroki Otani and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JID innovations : skin science from molecules to population health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Decay of Skin-Specific Gene Modules in Pangolins.Journal of molecular evolution · 2023
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Akari ShintaniDepartment of Anatomy, School of Medicine, Kanazawa Medical University, Uchinada, Japan.
Hiromi Sakata-HagaDepartment of Anatomy, School of Medicine, Kanazawa Medical University, Uchinada, Japan.
Keiichi MoriguchiDepartment of Oral Anatomy, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi, Japan.
Mitsuhiro TomosugiDepartment of Anatomy, School of Medicine, Kanazawa Medical University, Uchinada, Japan.
Daisuke SakaiDepartment of Biology, Kanazawa Medical University, Uchinada, Japan.
Tsuyoshi TsukadaDepartment of Anatomy, School of Medicine, Kanazawa Medical University, Uchinada, Japan.
Makoto TaniguchiDepartment of Life Science, Medical Research Institute, Kanazawa Medical University, Uchinada, Japan.
Masahide AsanoInstitute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hiroki ShimadaDepartment of Medical Science, School of Nursing, Kanazawa Medical University, Uchinada, Japan.
Hiroki OtaniDepartment of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Japan.
Hiroki ShojiDepartment of Biology, Kanazawa Medical University, Uchinada, Japan.
Junko HattaDepartment of Dermatology, School of Medicine, Kanazawa Medical University, Uchinada, Japan.
Takashi MochizukiDepartment of Dermatology, School of Medicine, Kanazawa Medical University, Uchinada, Japan.
Toshihisa HattaDepartment of Anatomy, School of Medicine, Kanazawa Medical University, Uchinada, Japan.
Kanazawa Medical University · JPAichi Gakuin University · JPKanazawa University · JPShimane University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MC5R is known for its role in the exocrine function of sebaceous glands, but other functions in the epidermis remain unclear. This study focused on the relationship between MC5R and homeostasis in the epidermis and examined the role of MC5R in mice whose skin was irradiated with UVB waves. UVB irradiation-induced skin ulcers and severe inflammation at lower doses in homozygotes of

Indexed as

KC, keratinocyteSG, stratum granulosumTEM, transmission electron microscopyTEWL, transepidermal water lossTGN, trans-Golgi networkTLC, thin-layer chromatographyWT, wild type

Identifiers

PMID34909724
PMCPMC8659802
OpenAlexW3164513884

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.