Evidence map›Paper›PMID 34909701›Full record

ArticleCritical care explorations2021

Extracorporeal Membrane Oxygenation Support for Influenza A: Retrospective Review of the Extracorporeal Life Support Organization Registry Comparing H1N1 With Other Subtypes.

Erika R O'Neil, Huiming Lin, Meng Li, Lara Shekerdemian, Joseph E Tonna, Ryan P Barbaro, Jayvee R Abella, Peter Rycus, Graeme MacLaren, Marc M Anders and 1 more

Open access · goldAbstract read
In one paragraph

Article in Critical care explorations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Predicting Mortality for Patients Eligible for Extracorporeal Membrane Oxygenation for COVID-19.American journal of respiratory and critical care medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Erika R O'NeilDepartment of Pediatrics, Baylor College of Medicine, Houston, TX.
Huiming LinDepartment of Statistics, Rice University, Houston, TX.
Meng LiDepartment of Statistics, Rice University, Houston, TX.
Lara ShekerdemianDepartment of Pediatrics, Baylor College of Medicine, Houston, TX.
Joseph E TonnaDivision of Emergency Medicine, Division of Cardiothoracic Surgery, University of Utah Health, Salt Lake City, UT.
Ryan P BarbaroDepartment of Pediatrics, University of Michigan, Ann Arbor, MI.
Jayvee R AbellaMedical Informatics Corporation, Houston, TX.
Peter RycusExtracorporeal Life Support Organization, Ann Arbor, MI.
Graeme MacLarenCardiothoracic Intensive Care Unit, National University Health System, Singapore.
Marc M AndersDepartment of Pediatrics, Baylor College of Medicine, Houston, TX.
Peta M A AlexanderDepartment of Cardiology, Boston Children's Hospital, Boston, MA.
Baylor College of Medicine · USRice University · USHarvard University · USNational University Health System · SGUniversity of Michigan–Ann Arbor · US

Funding

ASCEND (ARDS in Children and ECMO initiation strategies impact on Neuro-Development)R01HL153519 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARBARO, RYAN PASQUALE · 2020 to 2024
$3.4M
Training to Advance Care Through Implementation Science in Cardiac And Lung Illnesses (TACTICAL)K12HL138039 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARNES, GEOFFREY DOUGLAS, PRESCOTT, HALLIE CHRISTINE · 2017 to 2021
$3.1M
Optimizing Selection and Management of Cardiac Arrest Patients Treated with ECMOK23HL141596 · NHLBI · UNIVERSITY OF UTAH · PI TONNA, JOSEPH EDWARD · 2018 to 2022
$945k
Pediatric ECMO Anticoagulation Collaborative (PEACE) ConsensusR13HD104432 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI ALEXANDER, PETA-MAREE ANN, MUSZYNSKI, JENNIFER · 2021 to 2021
$75k
NHLBI NIH HHS K12 HL138039NHLBI NIH HHS K23 HL141596NHLBI NIH HHS R01 HL153519NICHD NIH HHS R13 HD104432
6 · The paper itself

Abstract

objectivesAlthough there is a substantial published experience of extracorporeal membrane oxygenation during the H1N1 pandemic, less is known about the use of extracorporeal membrane oxygenation in patients with other subtypes of the influenza A virus. We hypothesized that the severity of illness and survival of patients supported with extracorporeal membrane oxygenation would differ for those with H1N1 influenza A compared with other subtypes of influenza A. DESIGN SETTING PATIENTS: Retrospective study of extracorporeal membrane oxygenation-supported adults (> 18 yr) with influenza A viral infection reported to the Extracorporeal Life Support Organization Registry between 2009 and 2019. We describe the frequency and compare characteristics and factors associated with in-hospital survival using a least absolute shrinkage and selection operator regression analysis. MAIN OUTCOMES AND MEASURES: Of 2,461 patients supported with extracorporeal membrane oxygenation for influenza A, 445 had H1N1, and 2,004 had other subtypes of influenza A. H1N1 was the predominant subtype between 2009 and 2011. H1N1 patients were younger, with more severe illness at extracorporeal membrane oxygenation cannulation and higher reported extracorporeal membrane oxygenation complications than those with other influenza A subtypes. Patient characteristics including younger age and higher weight and patient management characteristics including longer ventilation duration before extracorporeal membrane oxygenation were associated with worse survival. Extracorporeal membrane oxygenation complications were associated with reduced survival. There was no difference in survival to hospital discharge according to influenza subtype after adjusting for other characteristics.

conclusionsPatients supported with extracorporeal membrane oxygenation for H1N1 were younger, with more severe illness than those supported for other influenza A subtypes. Survival to hospital discharge was associated with patient characteristics, management characteristics, and extracorporeal membrane oxygenation complications but was not impacted by the specific influenza A subtype.

Indexed as

acute respiratory distress syndromeextracorporeal membrane oxygenationrespiratory distress

Identifiers

PMID34909701
PMCPMC8663836
OpenAlexW4200240588

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.