ArticleCritical care explorations2021
Positive End-Expiratory Pressure and Respiratory Rate Modify the Association of Mechanical Power and Driving Pressure With Mortality Among Patients With Acute Respiratory Distress Syndrome.
Article in Critical care explorations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Assessment of mortality risk by respiratory rate-specific quartiles in mechanically ventilated patients with acute respiratory distress syndrome in Mexico.Internal and emergency medicine · 2026Observational
- Correlation of mechanical power and outcome in critically ill patients in Indian population: A prospective observational study.Indian journal of anaesthesia · 2026Article
- Exploring the association of mechanical power with mortality and phenotypes among patients with acute respiratory distress syndrome: a retrospective analysis.Frontiers in medicine · 2026Article
- Driving pressure vs. oxygenation-based PEEP titration strategies in ARDS patients: a physiological study.Critical care (London, England) · 2025Observational
- Association between mechanical power and intensive care unit mortality in Korean patients under pressure-controlled ventilation.Acute and critical care · 2024Article
- The Impact of Mechanical Energy Assessment on Mechanical Ventilation: A Comprehensive Review and Practical Application.Medical science monitor : international medical journal of experimental and clinical research · 2023Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
importanceMechanical power and driving pressure have known associations with survival for patients with acute respiratory distress syndrome.
objectivesTo further understand the relative importance of mechanical power and driving pressure as clinical targets for ventilator management.
designSecondary observational analysis of randomized clinical trial data. SETTING AND
participantsPatients with the acute respiratory distress syndrome from three Acute Respiratory Distress Syndrome Network trials. MAIN OUTCOMES AND MEASURES: After adjusting for patient severity in a multivariate Cox proportional hazards model, we examined the relative association of driving pressure and mechanical power with hospital mortality. Among 2,410 patients, the relationship between driving pressure and mechanical power with mortality was modified by respiratory rate, positive end-expiratory pressure, and flow.
resultsAmong patients with low respiratory rate (< 26), only power was significantly associated with mortality (power [hazard ratio, 1.82; 95% CI, 1.41-2.35; CONCLUSIONS AND RELEVANCE: The relationship between mechanical power and driving pressure with mortality differed within severity subgroups defined by positive end-expiratory pressure, respiratory rate, and airway flow.
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Registered trials
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