ArticleCurrent research in pharmacology and drug discovery2021
Endophytic fungi: A treasure trove of novel anticancer compounds.
Article in Current research in pharmacology and drug discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Genomic features and the transcriptional regulation of secondary metabolite biosynthesis of endophytic fungusMicrobial genomics · 2026Article
- Fungi as a source of anticancer agents: metabolic products and their functional implications.Archives of microbiology · 2026Review
- Bioprospecting endophytic fungi of forest plants for bioactive metabolites with anticancer potentials.Scientific reports · 2025Article
- Investigating the antimicrobial and anticancer potential of culturable fungal endophytes isolated from the stems of Kirkia acuminata Oliv.BMC microbiology · 2025Article
- Efficient production of the high-intensity natural sweetener siamenoside I by the exo-1,3-beta glucanase (Exo15) from3 Biotech · 2025Article
- A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment.Mycobiology · 2024Review
- Health-Promoting Effects of Bioactive Compounds from Plant Endophytic Fungi.Journal of fungi (Basel, Switzerland) · 2023Review
- Visualization of the relationship between fungi and cancer from the perspective of bibliometric analysis.Heliyon · 2023Article
- Natural Bacterial and Fungal Peptides as a Promising Treatment to Defeat Lung Cancer Cells.Molecules (Basel, Switzerland) · 2023Review
- Ethyl Acetate Extract ofACS omega · 2023Article
- Endophytic fungusPeerJ · 2023Article
- A Comprehensive in vitro and in silico Assessment on Inhibition of CYP51B and Ergosterol Biosynthesis by Eugenol in Rhizopus oryzae.Current microbiology · 2022Article
- Cytotoxic Potential ofCurrent issues in molecular biology · 2022Article
- Isolation, anticancer potency, and camptothecin-producing ability of endophytic fungi isolated fromScience progressArticle
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer is a multifactorial disease with a convoluted genesis and progression. The emergence of multidrug resistance to presently be offered drug and relapse is by far, the most critical concern to tackle this deteriorating disease. Henceforth, there is undeniably an inflated necessity for safe, promising, and less harmful new anticancer drugs. Natural compounds from various sources like plants, animals, and microorganisms have occupied a center stage in drug discovery due to their tremendous chemical diversity and potential as therapeutic agents. Endophytic microbes are symbiotically associated with plants and have been proven to produce novel or analogues of host bioactive metabolites exhibiting a variety of biological activities including anticancer activity. This review emphasizes on structurally diverse unprecedented anticancer natural compounds that have been reported exclusively from endophytic fungi from 2016 to 2020. It covers chemical nature of metabolites, its fungal source associated with terrestrial, as well as marine plants and anticancer activity based on their cytotoxicity profile against various cancer cell lines. Many of these fungal metabolites with promising anticancer activity can be used as lead molecules for
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