Evidence map›Paper›PMID 34909558›Full record

ArticleEnvironmental epidemiology (Philadelphia, Pa.)2021

Analysis of long- and medium-term particulate matter exposures and stroke in the US-based Health Professionals Follow-up Study.

Yenan Xu, Jarvis T Chen, Isabel Holland, Jeff D Yanosky, Duanping Liao, Brent A Coull, Dong Wang, Kathryn Rexrode, Eric A Whitsel, Gregory A Wellenius and 2 more

Open access · goldAbstract read
In one paragraph

Article in Environmental epidemiology (Philadelphia, Pa.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. The potential role of dietary patterns in modifying the association between ambient PMEnvironmental health : a global access science source · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Yenan XuDepartment of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA.
Jarvis T ChenDepartment of Social and Behavioral Sciences, Harvard TH Chan School of Public Health, Boston, MA.
Isabel HollandChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Jeff D YanoskyDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA.
Duanping LiaoDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA.
Brent A CoullDepartment of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA.
Dong WangChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Kathryn RexrodeDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Eric A WhitselDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.
Gregory A WelleniusDepartment of Environmental Health, Boston University School of Public Health, Boston, MA.
Francine LadenDepartment of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA.
Jaime E HartDepartment of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA.
Brigham and Women's Hospital · USHarvard University · USPennsylvania State University · USBoston University · USUniversity of North Carolina at Chapel Hill · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Training Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3M
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
Training Program in Environmental EpidemiologyT32ES007069 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LADEN, FRANCINE · 1985 to 2024
$13.9M
Dietary Etiology of Heart DiseaseR01HL035464 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ERIC B RIMM, Qi Sun · 1986 to 2026
$13.6M
Relationship Between Multiple Environmental Exposures and CVD Incidence and Survival: Vulnerability and SusceptibilityR01ES028033 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI DOMINICI, FRANCESCA, LADEN, FRANCINE · 2018 to 2022
$3.5M
Ambient Air Pollution and Incident StrokeR01ES020871 · NIEHS · BROWN UNIVERSITY · PI WELLENIUS, GREGORY A · 2012 to 2016
$2.7M
NCI NIH HHS T32 CA009001NCI NIH HHS U01 CA167552NCI NIH HHS UM1 CA186107NHLBI NIH HHS R01 HL035464NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES020871NIEHS NIH HHS R01 ES028033NIEHS NIH HHS T32 ES007069
6 · The paper itself

Abstract

purposeStroke is a leading cause of mortality worldwide, and air pollution is the third largest contributor to global stroke burden. Existing studies investigating the association between long-term exposure to particulate matter (PM) and stroke incidence have been mixed and very little is known about the associations with medium-term exposures. Therefore, we wanted to evaluate these associations in an cohort of male health professionals.

methodsWe assessed the association of PM exposures in the previous 1 and 12 months with incident total, ischemic, and hemorrhagic stroke in 49,603 men in the prospective US-based Health Professionals' Follow-up Study 1988-2007. We used spatiotemporal prediction models to estimate monthly PM less than 10 (PM

resultsWe observed 1,467 cases of incident stroke. Average levels of 12-month PM

conclusionsWe observed only weak evidence of an association between long-term exposure to PM and risks of overall incident stroke. There was a suggestion of increasing hemorrhagic stroke risk.

Indexed as

Air pollutionCohort studyIncidenceParticulate matterStoke

Identifiers

PMID34909558
PMCPMC8663831
OpenAlexW3211351997

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.