ReviewJournal of dental anesthesia and pain medicine2021
Adverse effects following dental local anesthesia: a literature review.
Review in Journal of dental anesthesia and pain medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Comparative evaluation of 2% mepivacaine and 2% lidocaine for inferior alveolar nerve block: a double-blind randomized clinical trial.BMC oral health · 2025Trial
- The effect of two different contemporary chelating agents on vital pulp therapy in mature permanent teeth with irreversible pulpitis using bioceramic material: randomized clinical trial.BMC oral health · 2024Trial
- Finite-Element Computer Modeling of Spatial Displacement of the Pterygoid Venous Plexus During Mandibular Movements.Journal of personalized medicine · 2026Article
- Safety Evaluation of Articaine and Lignocaine as Local Anesthetic Agents in Pediatric Dental Patients: A Systematic Review and Meta-analysis.International journal of clinical pediatric dentistry · 2026Article
- Late mandibular fracture after third molar extraction: a malpractice case or not?The Journal of forensic odonto-stomatology · 2025Article
- Evaluating the knowledge of general dental practitioners regarding local anesthetic injections in pediatric patients.Scientific reports · 2025Article
- Review of the Safety and Clinical Considerations of Vasoconstrictor Agents in Dental Anesthesia During Pregnancy.Journal of clinical medicine · 2025Review
- High-Frequency Ultrasound for Detecting Periodontal Inflammation: A Preclinical Diagnostic Accuracy Study.Journal of periodontal research · 2025Article
- Pain Management and Parafunctional Activity Secondary to Local Anesthesia in Children 4-12 Years Old-A Retrospective Study.Journal of clinical medicine · 2025Article
- Assessing dental students' awareness of anaphylactic shock caused by local anesthetic injection: a cross-sectional, descriptive-analytical study.BMC research notes · 2025Article
- Adrenaline dilution in dental local anesthetic: a preliminary study to prevent coring in cartridges.Journal of dental anesthesia and pain medicine · 2024Article
- Frequency and features of medical emergencies at a teaching dental hospital in Saudi Arabia: a 14-year retrospective observational study.BMC emergency medicine · 2024Observational
- Review
- Article
- Knowledge, Practice and Self-Reported Confidence Level of Croatian Dentists in the Use of Local Anesthesia: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2023Article
- HEMODYNAMIC FUNCTION IN COMPARISON OF TWO TYPES OF LOCAL ANESTHESIA WITH VASOCONSTRICTOR IN DAY SURGERY: RETROSPECTIVE STUDY.Acta clinica Croatica · 2022Article
- Accidental Insertion of a Broken Needle into the Pterygoid Mandibular Space during Inferior Alveolar Nerve Block: A Case Report.Case reports in dentistry · 2022Article
- Selection of the safest local anesthetic for dental treatment in medically compromised patients: A comprehensive review.Saudi journal of anaesthesiaReview
- Tissue Necrosis as a Rare Complication of Local Anaesthesia - A Case Series.Annals of maxillofacial surgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Local anesthesia is indispensable in dentistry. Worldwide, millions of local anesthetic injections are administered annually, and are generally considered safe invasive procedures. However, adverse effects are possible, of which dentists should be aware of. This scoping review aimed to provide an extensive overview of the reported literature on the adverse effects of dental local anesthesia. The types of papers, what is reported, and how they are reported were reviewed. Additionally, the incidence and duration of adverse effects and factors influencing their occurrence were also reviewed. An electronic search for relevant articles was performed in PubMed and Embase databases from inception to January 2, 2020. The titles and abstracts were independently screened by two reviewers. The analysis was narrative, and no meta-analysis was performed. This study included 78 articles. Ocular and neurological adverse effects, allergies, hematomas, needle breakage, tissue necrosis, blanching, jaw ankylosis, osteomyelitis, and isolated atrial fibrillation have been described. Multiple adverse effects of dental local anesthesia have been reported in the literature. The results were heterogeneous, and detailed descriptions of the related procedures were lacking. Vital information concerning adverse effects, such as the dosage or type of anesthetic solution, or the type of needle used, was frequently missing. Therefore, high-quality research on this topic is needed. Finally, the adverse effects that are rarely encountered in real-world general practice are overrepresented in the literature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.